Literature DB >> 2137123

Expression and reconstitution of a biologically active human interferon-gamma receptor in hamster cells.

V Jung1, C Jones, C S Kumar, S Stefanos, S O'Connell, S Pestka.   

Abstract

We report the expression of the human interferon-gamma (Hu-IFN-gamma) receptor from a cDNA clone in an animal cell where both stable expression of the cloned receptor as well as its biological activity is demonstrated for the first time. Biological activity of the receptor (i.e. expression of surface histocompatibility antigens in response to human interferon-gamma) requires the presence of human chromosome 21 demonstrating the requirement for at least one other species-specific factor in the modulation of receptor action. This system should now facilitate delineation of regions involved in the binding of human interferon-gamma and receptor signal transduction.

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Year:  1990        PMID： 2137123

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  11 in total

1.  The intracellular domain of interferon-alpha receptor 2c (IFN-alphaR2c) chain is responsible for Stat activation.

Authors:  S V Kotenko; L S Izotova; O V Mirochnitchenko; C Lee; S Pestka
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-27       Impact factor: 11.205

2.  Structural analysis of the human interferon gamma receptor: a small segment of the intracellular domain is specifically required for class I major histocompatibility complex antigen induction and antiviral activity.

Authors:  J R Cook; V Jung; B Schwartz; P Wang; S Pestka
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205

3.  Molecular cloning of a cDNA coding for mouse liver xanthine dehydrogenase. Regulation of its transcript by interferons in vivo.

Authors:  M Terao; G Cazzaniga; P Ghezzi; M Bianchi; F Falciani; P Perani; E Garattini
Journal:  Biochem J       Date:  1992-05-01       Impact factor: 3.857

4.  Efficient cloning of PCR generated DNA containing terminal restriction endonuclease recognition sites.

Authors:  V Jung; S B Pestka; S Pestka
Journal:  Nucleic Acids Res       Date:  1990-10-25       Impact factor: 16.971

5.  Altered synthesis of interferon-gamma and expression of interferon-gamma receptor by peripheral blood mononuclear cells from patients with IgA nephropathy and non-IgA proliferative glomerulonephritis.

Authors:  N Yano; M Endoh; R Naka; F Takemura; Y Nomoto; H Sakai
Journal:  J Clin Immunol       Date:  1996-01       Impact factor: 8.317

6.  Mutant human cells defective in induction of major histocompatibility complex class II genes by interferon gamma.

Authors:  C Mao; D Davies; I M Kerr; G R Stark
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205

7.  Functional characterization of a hybrid human-mouse interferon gamma receptor: evidence for species-specific interaction of the extracellular receptor domain with a putative signal transducer.

Authors:  S Hemmi; G Merlin; M Aguet
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-01       Impact factor: 11.205

8.  Identification of a functionally important sequence in the C terminus of the interferon-gamma receptor.

Authors:  M A Farrar; J D Campbell; R D Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-15       Impact factor: 11.205

9.  Identification of a yeast artificial chromosome clone encoding an accessory factor for the human interferon gamma receptor: evidence for multiple accessory factors.

Authors:  J Soh; R J Donnelly; T M Mariano; J R Cook; B Schwartz; S Pestka
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-15       Impact factor: 11.205

10.  The extracellular domain of the human interferon gamma receptor interacts with a species-specific signal transducer.

Authors:  V C Gibbs; S R Williams; P W Gray; R D Schreiber; D Pennica; G Rice; D V Goeddel
Journal:  Mol Cell Biol       Date:  1991-12       Impact factor: 4.272
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