OBJECTIVE: This study evaluated the influence of the family cluster effect on behavioral and psychological variables among individuals undergoing BRCA1/2 genetic testing for cancer susceptibility. METHODS: French-Canadian women (n = 552) and men (n = 104) from 140 different families undergoing BRCA1/2 testing between years 1998 and 2004 completed a self-administered questionnaire on a wide range of behavioral and psychological variables. The impact of the family cluster effect on 29 variables was assessed using the intraclass correlation coefficient (ICC) as computed from multilevel random-effect models. RESULTS: ICC values were statistically significant for 22 of the 29 variables. Overall, the mean ICC value was 0.10. The ICC values for knowledge about hereditary breast and ovarian cancer and frequency of alcohol consumption were 0.25. The ICC value for the Impact of Event Scale, which is a commonly used measure of cancer-specific distress, was 0.14. CONCLUSIONS: Our results suggest that the family cluster effect influences the majority of behavioral and psychosocial variables. When studying psychosocial aspects of genetic testing for cancer susceptibility, the family cluster effect should be routinely accounted for when determining sample size and statistical methods.
OBJECTIVE: This study evaluated the influence of the family cluster effect on behavioral and psychological variables among individuals undergoing BRCA1/2 genetic testing for cancer susceptibility. METHODS: French-Canadian women (n = 552) and men (n = 104) from 140 different families undergoing BRCA1/2 testing between years 1998 and 2004 completed a self-administered questionnaire on a wide range of behavioral and psychological variables. The impact of the family cluster effect on 29 variables was assessed using the intraclass correlation coefficient (ICC) as computed from multilevel random-effect models. RESULTS: ICC values were statistically significant for 22 of the 29 variables. Overall, the mean ICC value was 0.10. The ICC values for knowledge about hereditary breast and ovarian cancer and frequency of alcohol consumption were 0.25. The ICC value for the Impact of Event Scale, which is a commonly used measure of cancer-specific distress, was 0.14. CONCLUSIONS: Our results suggest that the family cluster effect influences the majority of behavioral and psychosocial variables. When studying psychosocial aspects of genetic testing for cancer susceptibility, the family cluster effect should be routinely accounted for when determining sample size and statistical methods.
Authors: Alexander Bauer; Jürgen F Riemann; Thomas Seufferlein; Max Reinshagen; Stephan Hollerbach; Ulrike Haug; Susanne Unverzagt; Stephanie Boese; Madeleine Ritter-Herschbach; Patrick Jahn; Thomas Frese; Michael Harris; Margarete Landenberger Journal: Dtsch Arztebl Int Date: 2018-10-26 Impact factor: 5.594
Authors: Kenneth P Tercyak; Darren Mays; Tiffani A DeMarco; Beth N Peshkin; Heiddis B Valdimarsdottir; Katherine A Schneider; Judy E Garber; Andrea Farkas Patenaude Journal: Cancer Epidemiol Biomarkers Prev Date: 2013-07 Impact factor: 4.254
Authors: Edo Richard; Susan Jongstra; Hilkka Soininen; Carol Brayne; Eric P Moll van Charante; Yannick Meiller; Bram van der Groep; Cathrien R L Beishuizen; Francesca Mangialasche; Mariagnese Barbera; Tiia Ngandu; Nicola Coley; Juliette Guillemont; Stéphanie Savy; Marcel G W Dijkgraaf; Ron J G Peters; Willem A van Gool; Miia Kivipelto; Sandrine Andrieu Journal: BMJ Open Date: 2016-06-10 Impact factor: 2.692