Regression of internal melanoma metastases following application of topical imiquimod to overlying skin.

The prognosis for metastatic melanoma is grim, and treatment options are limited. Imiquimod is a topically applied immune modulator that has been used to treat superficial cutaneous melanoma, but has not been reported to treat metastatic melanoma. We report a patient whose liver and iliac fossa melanoma metastases regressed after topical application of imiquimod cream to overlying skin. This supports further investigation of the potential use of imiquimod for metastatic melanoma.