Literature DB >> 21368584

Molecular Pharming: future targets and aspirations.

Mathew Paul1, Craig van Dolleweerd, Pascal M W Drake, Rajko Reljic, Harry Thangaraj, Tommaso Barbi, Elena Stylianou, Ilaria Pepponi, Leonard Both, Verena Hehle, Luisa Madeira, Varghese Inchakalody, Sammy Ho, Thais Guerra, Julian K-C Ma.   

Abstract

Molecular Pharming represents an unprecedented opportunity to manufacture affordable modern medicines and make these available at a global scale. The area of greatest potential is in the prevention of infectious diseases, particular in underdeveloped countries where access to medicines and vaccines has historically been limited. This is why, at St. George's, we focus on diseases such as HIV, TB and rabies, and aim to develop production strategies that are simple and potentially easy to transfer to developing countries.

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Year:  2011        PMID： 21368584      PMCID： PMC3230538          DOI： 10.4161/hv.7.3.14456

Source DB:  PubMed          Journal:  Hum Vaccin        ISSN： 1554-8600


  39 in total

Review 1.  Evolution of a regulatory framework for pharmaceuticals derived from genetically modified plants.

Authors:  Armin Spök; Richard M Twyman; Rainer Fischer; Julian K C Ma; Penelope A C Sparrow
Journal:  Trends Biotechnol       Date:  2008-09       Impact factor: 19.536

2.  HIV-1 p24-immunoglobulin fusion molecule: a new strategy for plant-based protein production.

Authors:  Patricia Obregon; Daniel Chargelegue; Pascal M W Drake; Alessandra Prada; James Nuttall; Lorenzo Frigerio; Julian K-C Ma
Journal:  Plant Biotechnol J       Date:  2006-03       Impact factor: 9.803

3.  Expanded impact of protein N-myristoylation in plants.

Authors:  José A Traverso; Thierry Meinnel; Carmela Giglione
Journal:  Plant Signal Behav       Date:  2008-07

4.  Glycosylphosphatidylinositol-anchored cell-surface proteins from Arabidopsis.

Authors:  D J Sherrier; T A Prime; P Dupree
Journal:  Electrophoresis       Date:  1999-07       Impact factor: 3.535

Review 5.  Modulation by epitope-specific antibodies of class II MHC-restricted presentation of the tetanus toxin antigen.

Authors:  C Watts; A Antoniou; B Manoury; E W Hewitt; L M Mckay; L Grayson; N F Fairweather; P Emsley; N Isaacs; P D Simitsek
Journal:  Immunol Rev       Date:  1998-08       Impact factor: 12.988

6.  Mucosal exposure to subinfectious doses of SIV primes gut-associated antibody-secreting cells and T cells: lack of enhancement by nonneutralizing antibody.

Authors:  N Polyanskaya; L A Bergmeier; S A Sharpe; N Cook; S Leech; G Hall; M Dennis; P ten Haaft; J Heeney; F Manca; T Lehner; M P Cranage
Journal:  Virology       Date:  2001-01-20       Impact factor: 3.616

7.  Secretion of a functional single-chain Fv protein in transgenic tobacco plants and cell suspension cultures.

Authors:  S Firek; J Draper; M R Owen; A Gandecha; B Cockburn; G C Whitelam
Journal:  Plant Mol Biol       Date:  1993-11       Impact factor: 4.076

8.  Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants.

Authors:  Qiang Chen; Junyun He; Waranyoo Phoolcharoen; Hugh S Mason
Journal:  Hum Vaccin       Date:  2011-03-01

9.  Improved virus neutralization by plant-produced anti-HIV antibodies with a homogeneous beta1,4-galactosylated N-glycan profile.

Authors:  Richard Strasser; Alexandra Castilho; Johannes Stadlmann; Renate Kunert; Heribert Quendler; Pia Gattinger; Jakub Jez; Thomas Rademacher; Friedrich Altmann; Lukas Mach; Herta Steinkellner
Journal:  J Biol Chem       Date:  2009-05-28       Impact factor: 5.157

10.  Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization.

Authors:  A Regnault; D Lankar; V Lacabanne; A Rodriguez; C Théry; M Rescigno; T Saito; S Verbeek; C Bonnerot; P Ricciardi-Castagnoli; S Amigorena
Journal:  J Exp Med       Date:  1999-01-18       Impact factor: 14.307
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  12 in total

1.  Efficient genetic transformation and regeneration system from hairy root of Origanum vulgare.

Authors:  Peyman Habibi; Maria Fatima Grossi de Sa; André Luís Lopes da Silva; Abdullah Makhzoum; Jefferson da Luz Costa; Ivo Albertto Borghetti; Carlos Ricardo Soccol
Journal:  Physiol Mol Biol Plants       Date:  2016-04-30

Review 2.  The Concept of Biosimilars: From Characterization to Evolution-A Narrative Review.

Authors:  Fadi Farhat; Alfredo Torres; Wungki Park; Gilberto de Lima Lopes; Raja Mudad; Chukwuemeka Ikpeazu; Simon Abi Aad
Journal:  Oncologist       Date:  2017-12-28

3.  Stable Expression of Adalimumab in Nicotiana tabacum.

Authors:  Tzvi Zvirin; Lena Magrisso; Amit Yaari; Oded Shoseyov
Journal:  Mol Biotechnol       Date:  2018-06       Impact factor: 2.695

4.  Single-dose monomeric HA subunit vaccine generates full protection from influenza challenge.

Authors:  Jyothi K Mallajosyula; Ernie Hiatt; Steve Hume; Ashley Johnson; Trushar Jeevan; Rachel Chikwamba; Gregory P Pogue; Barry Bratcher; Hugh Haydon; Richard J Webby; Alison A McCormick
Journal:  Hum Vaccin Immunother       Date:  2013-12-30       Impact factor: 3.452

5.  Assessment of heat shock protein 70 induction by heat in alfalfa varieties and constitutive overexpression in transgenic plants.

Authors:  Nicoletta Ferradini; Rina Iannacone; Stefano Capomaccio; Alessandra Metelli; Nadia Armentano; Lucia Semeraro; Francesco Cellini; Fabio Veronesi; Daniele Rosellini
Journal:  PLoS One       Date:  2015-05-07       Impact factor: 3.240

6.  New Hope for a "Cursed" Crop? Understanding Stakeholder Attitudes to Plant Molecular Farming With Modified Tobacco in Europe.

Authors:  Jonathan Menary; Mario Amato; Andrés Cid Sanchez; Matthew Hobbs; Agata Pacho; Sebastian S Fuller
Journal:  Front Plant Sci       Date:  2020-06-12       Impact factor: 5.753

7.  Combinatorial Analysis of Secretory Immunoglobulin A (sIgA) Expression in Plants.

Authors:  Paloma Juarez; Estefania Huet-Trujillo; Alejandro Sarrion-Perdigones; Erica Elvira Falconi; Antonio Granell; Diego Orzaez
Journal:  Int J Mol Sci       Date:  2013-03-18       Impact factor: 5.923

Review 8.  How can plant genetic engineering contribute to cost-effective fish vaccine development for promoting sustainable aquaculture?

Authors:  Jihong Liu Clarke; Mohammad Tahir Waheed; Andreas G Lössl; Inger Martinussen; Henry Daniell
Journal:  Plant Mol Biol       Date:  2013-06-01       Impact factor: 4.076

9.  Engineering, expression in transgenic plants and characterisation of E559, a rabies virus-neutralising monoclonal antibody.

Authors:  Craig J van Dolleweerd; Audrey Y-H Teh; Ashley C Banyard; Leonard Both; Hester C T Lotter-Stark; Tsepo Tsekoa; Baby Phahladira; Wonderful Shumba; Ereck Chakauya; Claude T Sabeta; Clemens Gruber; Anthony R Fooks; Rachel K Chikwamba; Julian K-C Ma
Journal:  J Infect Dis       Date:  2014-02-07       Impact factor: 5.226

10.  Plasma-Derived Polyreactive Secretory-Like IgA and IgM Opsonizing Salmonella enterica Typhimurium Reduces Invasion and Gut Tissue Inflammation through Agglutination.

Authors:  Gilles Bioley; Justine Monnerat; Marius Lötscher; Cédric Vonarburg; Adrian Zuercher; Blaise Corthésy
Journal:  Front Immunol       Date:  2017-08-29       Impact factor: 7.561
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