Literature DB >> 21367628

Sleep driving: sleepwalking variant or misuse of z-drugs?

Mark R Pressman1.   

Abstract

Sleep driving is most often classified as a variant of sleepwalking, but should be distinguished from impaired driving due to misuse or abuse of sedative/hypnotic drugs. Z-drugs; zolpidem and zopiclone in particular, have been associated with the majority of reported cases of impaired driving. Numerous studies have found z-drugs in driving under influence (DUI) related police stops, arrests and accidents. Impaired drivers are reported to have 1) blood levels of z-drugs that exceed therapeutic ranges 2) failed to take the medication at the correct time or remain in bed for sufficient time and/or 3) combined z-drugs with other central nervous system (CNS) depressants and/or alcohol. Consistent with CNS depression, z-drug-impaired drivers may demonstrate cognitive function at low levels with drivers still able to understand and respond to questions while sleepwalkers are completely unable to understand or interact with police. Z-drug-impaired drivers are often severely physically impaired, unable to stand up or maintain balance while sleepwalkers are able to stand and walk unaided. Sleep driving and impaired driving due to z-drugs may overlap. Sleep driving and drug-impaired driving are statistically rare events, but due to the billions of doses prescribed each year may still result in numerous DUI related arrests and accidents.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID: 21367628     DOI: 10.1016/j.smrv.2010.12.004

Source DB:  PubMed          Journal:  Sleep Med Rev        ISSN: 1087-0792            Impact factor:   11.609


  7 in total

1.  Middle-of-the-night hypnotic use in a large national health plan.

Authors:  Thomas Roth; Patricia Berglund; Victoria Shahly; Alicia C Shillington; Judith J Stephenson; Ronald C Kessler
Journal:  J Clin Sleep Med       Date:  2013-07-15       Impact factor: 4.062

2.  Zolpidem ingestion, automatisms, and sleep driving: a clinical and legal case series.

Authors:  J Steven Poceta
Journal:  J Clin Sleep Med       Date:  2011-12-15       Impact factor: 4.062

Review 3.  In the Zzz zone: the effects of Z-drugs on human performance and driving.

Authors:  Naren Gunja
Journal:  J Med Toxicol       Date:  2013-06

Review 4.  Hypnotic drug risks of mortality, infection, depression, and cancer: but lack of benefit.

Authors:  Daniel F Kripke
Journal:  F1000Res       Date:  2016-05-19

5.  'Z-trip'? A Comprehensive Overview and a Case-series of Zolpidem Misuse.

Authors:  Laura Orsolini; Stefania Chiappini; Paolo Grandinetti; Angelo Bruschi; Roberta Testa; Alessandra Provenzano; Domenico De Berardis; Umberto Volpe
Journal:  Clin Psychopharmacol Neurosci       Date:  2021-05-31       Impact factor: 2.582

6.  Is suvorexant a better choice than alternative hypnotics?

Authors:  Daniel F Kripke
Journal:  F1000Res       Date:  2015-08-03

Review 7.  Fast-Acting Sublingual Zolpidem for Middle-of-the-Night Wakefulness.

Authors:  Joseph V Pergolizzi; Robert Taylor; Robert B Raffa; Srinivas Nalamachu; Maninder Chopra
Journal:  Sleep Disord       Date:  2014-02-05
  7 in total

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