BACKGROUND: The majority of patients with cholinergic urticaria presents with strong hypersensitivity to autologous sweat. Patients with severe cholinergic urticaria are frequently resistant to H(1) antagonists which are used in conventional therapies for various types of urticaria. It has been reported that desensitization using partially purified sweat antigen was effective in a patient with cholinergic urticaria. METHODS: The aim of this study is to determine the usefulness of rapid desensitization with autologous sweat in severe cholinergic urticaria, because rapid desensitization has proven to be a quick and effective immunotherapy for allergies to various allergens. Six patients with severe cholinergic urticaria who are resistant to H(1) antagonists and have sweat hypersensitivity were enrolled in a rapid desensitization protocol. RESULTS: In all six patients, the responses for skin tests with autologous sweat were attenuated after rapid desensitization with autologous sweat. Two of the three cholinergic urticaria patients showed reduced histamine release with autologous sweat after the rapid desensitization with autologous sweat. Further, the rapid desensitization and subsequent maintenance treatment reduced the symptoms in five of the six patients. CONCLUSIONS: This study provides evidence that rapid desensitization with autologous sweat is beneficial for treating cholinergic urticaria patients resistant to conventional therapy who have sweat hypersensitivity.
BACKGROUND: The majority of patients with cholinergic urticaria presents with strong hypersensitivity to autologous sweat. Patients with severe cholinergic urticaria are frequently resistant to H(1) antagonists which are used in conventional therapies for various types of urticaria. It has been reported that desensitization using partially purified sweat antigen was effective in a patient with cholinergic urticaria. METHODS: The aim of this study is to determine the usefulness of rapid desensitization with autologous sweat in severe cholinergic urticaria, because rapid desensitization has proven to be a quick and effective immunotherapy for allergies to various allergens. Six patients with severe cholinergic urticaria who are resistant to H(1) antagonists and have sweat hypersensitivity were enrolled in a rapid desensitization protocol. RESULTS: In all six patients, the responses for skin tests with autologous sweat were attenuated after rapid desensitization with autologous sweat. Two of the three cholinergic urticariapatients showed reduced histamine release with autologous sweat after the rapid desensitization with autologous sweat. Further, the rapid desensitization and subsequent maintenance treatment reduced the symptoms in five of the six patients. CONCLUSIONS: This study provides evidence that rapid desensitization with autologous sweat is beneficial for treating cholinergic urticariapatients resistant to conventional therapy who have sweat hypersensitivity.
Authors: Maria Maddalena Sirufo; Alessandra Catalogna; Martina Raggiunti; Francesca De Pietro; Lia Ginaldi; Massimo De Martinis Journal: Clin Cosmet Investig Dermatol Date: 2022-02-18
Authors: Kanokvalai Kulthanan; Martin K Church; Eva Maria Grekowitz; Tomasz Hawro; Lea Alice Kiefer; Kanyalak Munprom; Yanisorn Nanchaipruek; Chuda Rujitharanawong; Dorothea Terhorst-Molawi; Marcus Maurer Journal: Front Immunol Date: 2022-07-28 Impact factor: 8.786
Authors: Jung Eun Kim; Young Sun Eun; Young Min Park; Hyun Jeong Park; Dong Su Yu; Hoon Kang; Sang Hyun Cho; Chul Jong Park; Si Yong Kim; Jun Young Lee Journal: Ann Dermatol Date: 2014-04-30 Impact factor: 1.444