Literature DB >> 21364090

A major gene effect controls resistance to caries.

R I Werneck1, F P Lázaro, A Cobat, A V Grant, M B Xavier, L Abel, A Alcaïs, P C Trevilatto, M T Mira.   

Abstract

Despite recent advances revealing genetic factors influencing caries susceptibility, questions regarding the model of inheritance involved are yet to be addressed. We conducted a Complex Segregation Analysis on decayed teeth in a sample of homogenous, isolated families recruited from the Brazilian Amazon. A dominant, major gene effect controlling resistance to phenotype was detected. The frequency of the resistance allele "A" was 0.63; mean numbers of decayed teeth were 1.53 and 9.53 for genotypes AA/AB and BB, respectively. These results represent a step toward a description of the exact nature of the genetic risk factors controlling human susceptibility to caries.

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Year:  2011        PMID： 21364090      PMCID： PMC3318028          DOI： 10.1177/0022034510397614

Source DB:  PubMed          Journal:  J Dent Res        ISSN： 0022-0345            Impact factor:   6.116


  20 in total

1.  The infectious and transmissible nature of experimental dental caries. Findings and implications.

Authors:  P H KEYES
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2.  Caries Risk: Individual and Population Perspectives. Proceedings of a Symposium at the 81st Annual Meeting of the International Association for Dental Research (IADR). Göteborg, Sweden, 28 June 2003.

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3.  Risk factors and risk indicators associated with high caries experience in Swedish 19-year-olds.

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4.  Complex segregation analyses: uses and limitations.

Authors:  G P Jarvik
Journal:  Am J Hum Genet       Date:  1998-10       Impact factor: 11.025

5.  A general model for the genetic analysis of pedigree data.

Authors:  R C Elston; J Stewart
Journal:  Hum Hered       Date:  1971       Impact factor: 0.444

6.  Regressive logistic models for familial disease and other binary traits.

Authors:  G E Bonney
Journal:  Biometrics       Date:  1986-09       Impact factor: 2.571

7.  The antimicrobial peptide DEFB1 is associated with caries.

Authors:  A Ozturk; P Famili; A R Vieira
Journal:  J Dent Res       Date:  2010-04-06       Impact factor: 6.116

Review 8.  Sex differences in dental caries experience: clinical evidence, complex etiology.

Authors:  John R Lukacs
Journal:  Clin Oral Investig       Date:  2010-07-21       Impact factor: 3.573

Review 9.  A critical review: an overview of genetic influence on dental caries.

Authors:  R I Werneck; M T Mira; P C Trevilatto
Journal:  Oral Dis       Date:  2010-10       Impact factor: 3.511

Review 10.  Changing paradigms in concepts on dental caries: consequences for oral health care.

Authors:  O Fejerskov
Journal:  Caries Res       Date:  2004 May-Jun       Impact factor: 4.056
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  7 in total

Review 1.  Caries: review of human genetics research.

Authors:  Alexandre R Vieira; Adriana Modesto; Mary L Marazita
Journal:  Caries Res       Date:  2014-05-21       Impact factor: 4.056

2.  Role of TRAV locus in low caries experience.

Authors:  Jessica Briseño-Ruiz; Takehiko Shimizu; Kathleen Deeley; Piper M Dizak; Timothy D Ruff; Italo M Faraco; Fernando A Poletta; João A Brancher; Giovana D Pecharki; Erika C Küchler; Patricia N Tannure; Andrea Lips; Thays C S Vieira; Asli Patir; Mine Koruyucu; Juan C Mereb; Judith M Resick; Carla A Brandon; Ariadne Letra; Renato M Silva; Margaret E Cooper; Figen Seymen; Marcelo C Costa; José M Granjeiro; Paula C Trevilatto; Iêda M Orioli; Eduardo E Castilla; Mary L Marazita; Alexandre R Vieira
Journal:  Hum Genet       Date:  2013-05-09       Impact factor: 4.132

3.  NOD2 and CCDC122-LACC1 genes are associated with leprosy susceptibility in Brazilians.

Authors:  Carolinne Sales-Marques; Heloisa Salomão; Vinicius Medeiros Fava; Lucia Elena Alvarado-Arnez; Evaldo Pinheiro Amaral; Cynthia Chester Cardoso; Ida Maria Foschiani Dias-Batista; Weber Laurentino da Silva; Priscila Medeiros; Marcos da Cunha Lopes Virmond; Francisco Carlos Félix Lana; Antonio Guilherme Pacheco; Milton Ozório Moraes; Marcelo Távora Mira; Ana Carla Pereira Latini
Journal:  Hum Genet       Date:  2014-11-04       Impact factor: 4.132

4.  Deficiency of Mineralization-Regulating Transcription Factor Trps1 Compromises Quality of Dental Tissues and Increases Susceptibility to Dental Caries.

Authors:  Mairobys Socorro; Priyanka Hoskere; Catherine Roberts; Lyudmila Lukashova; Kostas Verdelis; Elia Beniash; Dobrawa Napierala
Journal:  Front Dent Med       Date:  2022-04-11

5.  Fine-mapping of 5q12.1-13.3 unveils new genetic contributors to caries.

Authors:  T Shimizu; K Deeley; J Briseño-Ruiz; I M Faraco; F A Poletta; J A Brancher; G D Pecharki; E C Küchler; P N Tannure; A Lips; T C S Vieira; A Patir; M Yildirim; J C Mereb; J M Resick; C A Brandon; M E Cooper; F Seymen; M C Costa; J M Granjeiro; P C Trevilatto; I M Orioli; E E Castilla; M L Marazita; A R Vieira
Journal:  Caries Res       Date:  2013-01-30       Impact factor: 4.056

6.  Heritable patterns of tooth decay in the permanent dentition: principal components and factor analyses.

Authors:  John R Shaffer; Eleanor Feingold; Xiaojing Wang; Karen T Tcuenco; Daniel E Weeks; Rebecca S DeSensi; Deborah E Polk; Steve Wendell; Robert J Weyant; Richard Crout; Daniel W McNeil; Mary L Marazita
Journal:  BMC Oral Health       Date:  2012-03-09       Impact factor: 2.757

7.  Analysis of polymorphisms in the lactotransferrin gene promoter and dental caries.

Authors:  João Armando Brancher; Giovana Daniela Pecharki; Andrea Duarte Doetzer; Kamilla Gabriella Dos Santos Medeiros; Carlos Alberto Cordeiro Júnior; Vanessa Santos Sotomaior; Peter Bauer; Paula Cristina Trevilatto
Journal:  Int J Dent       Date:  2011-12-08
  7 in total

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