Literature DB >> 2136382

Characterization of Leishmania donovani variant clones using anti-lipophosphoglycan monoclonal antibodies.

T B McNeely1, D L Tolson, T W Pearson, S J Turco.   

Abstract

Monoclonal antibodies directed against the lipophosphoglycan of Leishmania donovani were used to characterize two glycosylation variants of the parasite. One of the variants was found to be totally deficient in the synthesis and expression of lipophosphoglycan. The other variant synthesized lower levels (20%) of the glycoconjugate compared to wildtype cells and its lipophosphoglycan was smaller in size. The two lipophosphoglycan-deficient clones will be useful for elucidating the biosynthesis and function of the glycoconjugate.

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Year:  1990        PMID： 2136382     DOI： 10.1093/glycob/1.1.63

Source DB:  PubMed          Journal:  Glycobiology        ISSN： 0959-6658            Impact factor:   4.313


  12 in total

1.  AuBr(3) mediated glycosidations: synthesis of tetrasaccharide motif of the Leishmania donovani lipophosphoglycan.

Authors:  Gopalsamy Sureshkumar; Srinivas Hotha
Journal:  Glycoconj J       Date:  2012-06-03       Impact factor: 2.916

2.  The role of phosphoglycans in Leishmania-sand fly interactions.

Authors:  D L Sacks; G Modi; E Rowton; G Späth; L Epstein; S J Turco; S M Beverley
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-04       Impact factor: 11.205

3.  Inhibition of phagolysosomal biogenesis by the Leishmania lipophosphoglycan.

Authors:  M Desjardins; A Descoteaux
Journal:  J Exp Med       Date:  1997-06-16       Impact factor: 14.307

4.  The kinetoplastid membrane protein 11 of Leishmania donovani and African trypanosomes is a potent stimulator of T-lymphocyte proliferation.

Authors:  D L Tolson; A Jardim; L F Schnur; C Stebeck; C Tuckey; R P Beecroft; H S Teh; R W Olafson; T W Pearson
Journal:  Infect Immun       Date:  1994-11       Impact factor: 3.441

5.  Extracellular release of the surface metalloprotease, gp63, from Leishmania and insect trypanosomatids.

Authors:  Charles L Jaffe; Dennis M Dwyer
Journal:  Parasitol Res       Date:  2003-08-16       Impact factor: 2.289

6.  Isolation of virulence genes directing surface glycosyl-phosphatidylinositol synthesis by functional complementation of Leishmania.

Authors:  K A Ryan; L A Garraway; A Descoteaux; S J Turco; S M Beverley
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-15       Impact factor: 11.205

7.  An avirulent lipophosphoglycan-deficient Leishmania major clone induces CD4+ T cells which protect susceptible BALB/c mice against infection with virulent L. major.

Authors:  P B Kimsey; C M Theodos; T K Mitchen; S J Turco; R G Titus
Journal:  Infect Immun       Date:  1993-12       Impact factor: 3.441

8.  Leishmania LPG3 encodes a GRP94 homolog required for phosphoglycan synthesis implicated in parasite virulence but not viability.

Authors:  Albert Descoteaux; Herbert A Avila; Kai Zhang; Salvatore J Turco; Stephen M Beverley
Journal:  EMBO J       Date:  2002-09-02       Impact factor: 11.598

9.  Distribution of lipophosphoglycan-associated epitopes in different Leishmania species and in African trypanosomes.

Authors:  D L Tolson; L F Schnur; A Jardim; T W Pearson
Journal:  Parasitol Res       Date:  1994       Impact factor: 2.289

10.  Innate immune activation and subversion of Mammalian functions by leishmania lipophosphoglycan.

Authors:  Luis H Franco; Stephen M Beverley; Dario S Zamboni
Journal:  J Parasitol Res       Date:  2012-02-22
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