OBJECTIVE: To assess the kinetics of response to certolizumab pegol (CZP), and association between rapid response and longterm outcomes, in patients with active rheumatoid arthritis (RA). METHODS: This was a post-hoc analysis of the randomized, double-blind RAPID 1 study in patients who received methotrexate (MTX) and either CZP 200 mg subcutaneously or placebo every 2 weeks for 52 weeks. Clinical and radiographic outcomes at Week 52 were evaluated based on the Disease Activity Score 28 (DAS28) ≥ 1.2 and American College of Rheumatology 20% (ACR20) responses at Week 6 and Week 12. RESULTS: Clinical responses [European League Against Rheumatism (EULAR), DAS28 ≥ 1.2, and ACR20 responses] were rapid in CZP-treated patients. Week 12 DAS28 ≥ 1.2 responders had better clinical and radiographic outcomes at Week 52 compared with nonresponders. Among Week 12 responders, incremental benefit of earlier response was observed: Week 6 DAS28 ≥ 1.2 responders and ACR20 responders had significantly higher ACR response rates and were more likely to achieve remission at Week 52 than Week 12 responders. Patients with a clinical response at Week 6 had faster, more meaningful sustained improvements in patient-derived outcomes than those responding by Week 12 only. CONCLUSION: Rapid attainment of clinical response in patients with RA is associated with improved longterm outcomes. Analysis of the kinetics of response to CZP during the first 12 weeks of therapy potentially permits informed prediction of clinical success or need to alter treatment. In patients not achieving a clinical response at Week 12 treatment adjustment should be considered. Trial registration NCT00152386.
RCT Entities:
OBJECTIVE: To assess the kinetics of response to certolizumab pegol (CZP), and association between rapid response and longterm outcomes, in patients with active rheumatoid arthritis (RA). METHODS: This was a post-hoc analysis of the randomized, double-blind RAPID 1 study in patients who received methotrexate (MTX) and either CZP 200 mg subcutaneously or placebo every 2 weeks for 52 weeks. Clinical and radiographic outcomes at Week 52 were evaluated based on the Disease Activity Score 28 (DAS28) ≥ 1.2 and American College of Rheumatology 20% (ACR20) responses at Week 6 and Week 12. RESULTS: Clinical responses [European League Against Rheumatism (EULAR), DAS28 ≥ 1.2, and ACR20 responses] were rapid in CZP-treated patients. Week 12 DAS28 ≥ 1.2 responders had better clinical and radiographic outcomes at Week 52 compared with nonresponders. Among Week 12 responders, incremental benefit of earlier response was observed: Week 6 DAS28 ≥ 1.2 responders and ACR20 responders had significantly higher ACR response rates and were more likely to achieve remission at Week 52 than Week 12 responders. Patients with a clinical response at Week 6 had faster, more meaningful sustained improvements in patient-derived outcomes than those responding by Week 12 only. CONCLUSION: Rapid attainment of clinical response in patients with RA is associated with improved longterm outcomes. Analysis of the kinetics of response to CZP during the first 12 weeks of therapy potentially permits informed prediction of clinical success or need to alter treatment. In patients not achieving a clinical response at Week 12 treatment adjustment should be considered. Trial registration NCT00152386.
Authors: Jeffrey R Curtis; Theresa McVie; Ted R Mikuls; Richard J Reynolds; Iris Navarro-Millán; James O'Dell; Larry W Moreland; S Louis Bridges; Veena K Ranganath; Stacey S Cofield Journal: J Rheumatol Date: 2013-04-15 Impact factor: 4.666
Authors: Vivian P Bykerk; Gerd R Burmester; Bernard G Combe; Daniel E Furst; Tom W J Huizinga; Harris A Ahmad; Paul Emery Journal: Rheumatol Int Date: 2018-10-20 Impact factor: 2.631
Authors: Vibeke Strand; Josef S Smolen; Ronald F van Vollenhoven; Philip Mease; Gerd R Burmester; Falk Hiepe; Dinesh Khanna; Enkeleida Nikaï; Geoffroy Coteur; Michael Schiff Journal: Ann Rheum Dis Date: 2011-03-17 Impact factor: 19.103
Authors: Josef S Smolen; Ronald van Vollenhoven; Arthur Kavanaugh; Vibeke Strand; Jiri Vencovsky; Michael Schiff; Robert Landewé; Boulos Haraoui; Catherine Arendt; Irina Mountian; David Carter; Désirée van der Heijde Journal: Arthritis Res Ther Date: 2015-09-10 Impact factor: 5.156
Authors: Jeffrey R Curtis; Melvin Churchill; Alan Kivitz; Ahmed Samad; Laura Gauer; Leon Gervitz; Willem Koetse; Jeffrey Melin; Yusuf Yazici Journal: Arthritis Rheumatol Date: 2015-12 Impact factor: 10.995