AIM: To evaluate outcomes of late preterm (34-36 6/7 weeks gestation) infants with congenital heart defects requiring surgical intervention during initial admission (added), in comparison with term (37-42 weeks) controls. METHODS: This was a retrospective chart review of consecutive late preterm and term infants with congenital heart lesions, requiring surgical intervention during initial admission. RESULTS: Our cohort (n=88) comprised 26 late preterm infants (group 1) and 62 term controls (group 2). The two groups differed significantly in mean (SD) gestation [34.5 (1.5) vs. 39.1 (1) weeks)], birth weight [2335 (402) vs. 3173 (401) g] and weight [2602 (739) vs. 3273 (507) g] and age [33 (51) vs. 11 (14) days] at surgery. Cardiac diagnosis frequencies were similar in both groups. The mean (SD) duration of PGE1 [31.9 (56.8) vs. 11.3 (24.9) days] and need for preoperative pressors (25% vs. 8%) were significantly higher in group 1. Death (23% vs. 8%, p=0.05) tended to be higher in group 1. Rates of necrotizing enterocolitis (23% vs. 1.7%), seizures (19% vs. 0%), oxygen need (12% vs. 0%) and gavage feeds (12% vs. 1.6%) at discharge were all significantly higher in the late preterm cohort. CONCLUSIONS: These data highlight the extreme vulnerability of infants with the 'double hits' of prematurity and heart defects.
AIM: To evaluate outcomes of late preterm (34-36 6/7 weeks gestation) infants with congenital heart defects requiring surgical intervention during initial admission (added), in comparison with term (37-42 weeks) controls. METHODS: This was a retrospective chart review of consecutive late preterm and term infants with congenital heart lesions, requiring surgical intervention during initial admission. RESULTS: Our cohort (n=88) comprised 26 late preterm infants (group 1) and 62 term controls (group 2). The two groups differed significantly in mean (SD) gestation [34.5 (1.5) vs. 39.1 (1) weeks)], birth weight [2335 (402) vs. 3173 (401) g] and weight [2602 (739) vs. 3273 (507) g] and age [33 (51) vs. 11 (14) days] at surgery. Cardiac diagnosis frequencies were similar in both groups. The mean (SD) duration of PGE1 [31.9 (56.8) vs. 11.3 (24.9) days] and need for preoperative pressors (25% vs. 8%) were significantly higher in group 1. Death (23% vs. 8%, p=0.05) tended to be higher in group 1. Rates of necrotizing enterocolitis (23% vs. 1.7%), seizures (19% vs. 0%), oxygen need (12% vs. 0%) and gavage feeds (12% vs. 1.6%) at discharge were all significantly higher in the late preterm cohort. CONCLUSIONS: These data highlight the extreme vulnerability of infants with the 'double hits' of prematurity and heart defects.
Authors: Lisa B Paquette; Jodie K Votava-Smith; Rafael Ceschin; Arabhi C Nagasunder; Hollie A Jackson; Stefan Blüml; Jessica L Wisnowski; Ashok Panigrahy Journal: Pediatr Cardiol Date: 2015-01-22 Impact factor: 1.655
Authors: L B Paquette; J L Wisnowski; R Ceschin; J D Pruetz; J A Detterich; S Del Castillo; A C Nagasunder; R Kim; M J Painter; F H Gilles; M D Nelson; R G Williams; S Blüml; A Panigrahy Journal: AJNR Am J Neuroradiol Date: 2013-05-23 Impact factor: 3.825
Authors: Nancy S Ghanayem; Kerstin R Allen; Sarah Tabbutt; Andrew M Atz; Martha L Clabby; David S Cooper; Pirooz Eghtesady; Peter C Frommelt; Peter J Gruber; Kevin D Hill; Jonathan R Kaltman; Peter C Laussen; Alan B Lewis; Karen J Lurito; L LuAnn Minich; Richard G Ohye; Julie V Schonbeck; Steven M Schwartz; Rakesh K Singh; Caren S Goldberg Journal: J Thorac Cardiovasc Surg Date: 2012-07-11 Impact factor: 5.209