PURPOSE: Decorin, p57(KIP2), and TGF-beta 1 have been investigated as prognostic factors because they appear to be associated with tumorigenesis; however, the effect of decorin and p57(KIP2) in lung cancer remains poorly understood. The purpose of this study was to examine the expression of decorin, p57(KIP2), and TGF-beta 1 in 64 lung cancer specimens and 36 normal lung specimens, and to analyze the relationships with respect to clinicopathological features and patient survival in lung cancer. METHODS: The expression levels of decorin, p57(KIP2), and TGF-beta 1 were examined by in situ hybridization and immunohistochemistry. RESULTS: Normal tissues exhibited a higher expression level of decorin than tumor tissues (p<0.05) and tumor tissues exhibited a higher expression level of TGF-beta 1 than normal tissues (p<0.05). The expression levels of p57(KIP2) and TGF-beta 1 were significantly associated with histological types of lung cancer (p<0.05), and the expression levels of decorin and p57(KIP2) were significantly associated with lymphatic invasion (p<0.05). Moreover, increased expression of decorin and p57(KIP2) correlated with increased survival (decorin, p=0.018; p57(KIP2), p=0.012). CONCLUSION: Decreased expression levels of decorin and p57(KIP2) were associated with poor postsurgical survival time and lymphatic metastasis in lung cancer patients; moreover, low expression was an adverse prognostic factor.
PURPOSE:Decorin, p57(KIP2), and TGF-beta 1 have been investigated as prognostic factors because they appear to be associated with tumorigenesis; however, the effect of decorin and p57(KIP2) in lung cancer remains poorly understood. The purpose of this study was to examine the expression of decorin, p57(KIP2), and TGF-beta 1 in 64 lung cancer specimens and 36 normal lung specimens, and to analyze the relationships with respect to clinicopathological features and patient survival in lung cancer. METHODS: The expression levels of decorin, p57(KIP2), and TGF-beta 1 were examined by in situ hybridization and immunohistochemistry. RESULTS: Normal tissues exhibited a higher expression level of decorin than tumor tissues (p<0.05) and tumor tissues exhibited a higher expression level of TGF-beta 1 than normal tissues (p<0.05). The expression levels of p57(KIP2) and TGF-beta 1 were significantly associated with histological types of lung cancer (p<0.05), and the expression levels of decorin and p57(KIP2) were significantly associated with lymphatic invasion (p<0.05). Moreover, increased expression of decorin and p57(KIP2) correlated with increased survival (decorin, p=0.018; p57(KIP2), p=0.012). CONCLUSION: Decreased expression levels of decorin and p57(KIP2) were associated with poor postsurgical survival time and lymphatic metastasis in lung cancerpatients; moreover, low expression was an adverse prognostic factor.
Authors: Simone Buraschi; Thomas Neill; Rick T Owens; Leonardo A Iniguez; George Purkins; Rajanikanth Vadigepalli; Barry Evans; Liliana Schaefer; Stephen C Peiper; Zi-Xuan Wang; Renato V Iozzo Journal: PLoS One Date: 2012-09-19 Impact factor: 3.240
Authors: Simon Schimmack; Andrew Taylor; Ben Lawrence; Daniele Alaimo; Hubertus Schmitz-Winnenthal; Markus W Büchler; Irvin M Modlin; Mark Kidd Journal: Epigenetics Chromatin Date: 2014-07-21 Impact factor: 4.954