AIMS/HYPOTHESIS: The aim of this study was to provide evidence that the anterior chamber of the eye serves as a novel clinical islet implantation site. METHODS: In a preclinical model, allogeneic pancreatic islets were transplanted into the anterior chamber of the eye of a baboon model for diabetes, and metabolic and ophthalmological outcomes were assessed. RESULTS: Islets readily engrafted on the iris and there was a decrease in exogenous insulin requirements due to insulin secretion from the intraocular grafts. No major adverse effects on eye structure and function could be observed during the transplantation period. CONCLUSIONS/ INTERPRETATION: Our study demonstrates the long-term survival and function of allogeneic islets after transplantation into the anterior chamber of the eye. The safety and simplicity of this procedure provides support for further studies aimed at translating this technology into the clinic.
AIMS/HYPOTHESIS: The aim of this study was to provide evidence that the anterior chamber of the eye serves as a novel clinical islet implantation site. METHODS: In a preclinical model, allogeneic pancreatic islets were transplanted into the anterior chamber of the eye of a baboon model for diabetes, and metabolic and ophthalmological outcomes were assessed. RESULTS: Islets readily engrafted on the iris and there was a decrease in exogenous insulin requirements due to insulin secretion from the intraocular grafts. No major adverse effects on eye structure and function could be observed during the transplantation period. CONCLUSIONS/ INTERPRETATION: Our study demonstrates the long-term survival and function of allogeneic islets after transplantation into the anterior chamber of the eye. The safety and simplicity of this procedure provides support for further studies aimed at translating this technology into the clinic.
Authors: N S Kenyon; M Chatzipetrou; M Masetti; A Ranuncoli; M Oliveira; J L Wagner; A D Kirk; D M Harlan; L C Burkly; C Ricordi Journal: Proc Natl Acad Sci U S A Date: 1999-07-06 Impact factor: 11.205
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Authors: N S Kenyon; L A Fernandez; R Lehmann; M Masetti; A Ranuncoli; M Chatzipetrou; G Iaria; D Han; J L Wagner; P Ruiz; M Berho; L Inverardi; R Alejandro; D H Mintz; A D Kirk; D M Harlan; L C Burkly; C Ricordi Journal: Diabetes Date: 1999-07 Impact factor: 9.461
Authors: A M James Shapiro; Camillo Ricordi; Bernhard J Hering; Hugh Auchincloss; Robert Lindblad; R Paul Robertson; Antonio Secchi; Mathias D Brendel; Thierry Berney; Daniel C Brennan; Enrico Cagliero; Rodolfo Alejandro; Edmond A Ryan; Barbara DiMercurio; Philippe Morel; Kenneth S Polonsky; Jo-Anna Reems; Reinhard G Bretzel; Federico Bertuzzi; Tatiana Froud; Raja Kandaswamy; David E R Sutherland; George Eisenbarth; Miriam Segal; Jutta Preiksaitis; Gregory S Korbutt; Franca B Barton; Lisa Viviano; Vicki Seyfert-Margolis; Jeffrey Bluestone; Jonathan R T Lakey Journal: N Engl J Med Date: 2006-09-28 Impact factor: 91.245
Authors: Rahul Krishnan; Rajan P Arora; Michael Alexander; Sean M White; Morgan W Lamb; Clarence E Foster; Bernard Choi; Jonathan R T Lakey Journal: Biomaterials Date: 2013-10-29 Impact factor: 12.479
Authors: Midhat H Abdulreda; Dora M Berman; Alexander Shishido; Christopher Martin; Maged Hossameldin; Ashley Tschiggfrie; Luis F Hernandez; Ana Hernandez; Camillo Ricordi; Jean-Marie Parel; Ewa Jankowska-Gan; William J Burlingham; Esdras A Arrieta-Quintero; Victor L Perez; Norma S Kenyon; Per-Olof Berggren Journal: Diabetologia Date: 2019-01-31 Impact factor: 10.122