BACKGROUND: Although the increased risk of developing pancreatic cancer (PC) in families with a strong history of the disease is well known, characteristics and outcomes of patients with familial PC is not described well. AIMS: This study aims to evaluate outcomes following resection in patients with familial PC. METHODS: We studied 208 patients who underwent resection of PC from 2000 to 2007 and had prospectively completed family history questionnaires for the Biospecimen Resource for Pancreas Research at our institution. We compared clinical characteristics and outcomes of familial and sporadic PC patients. RESULTS: Familial (N = 15) and sporadic PC patients (N = 193) did not have significantly different demographics, pre-operative CA19-9, pre-operative weight loss, R0 status, or T-staging (all p ≥ 0.05). Familial PC patients had lower pre-operative total serum bilirubin concentrations (p = 0.03) and lesions outside of the pancreatic head more frequently (p = 0.02) than sporadic PC patients. There was no difference in survival at 2 years between familial and sporadic PC patients (p = 0.52). CONCLUSIONS: Familial PC patients appear to develop tumors outside of the pancreatic head more frequently than sporadic PC patients. This difference in tumor distribution may be due to a broader area of cancer susceptibility within the pancreas for familial PC patients.
BACKGROUND: Although the increased risk of developing pancreatic cancer (PC) in families with a strong history of the disease is well known, characteristics and outcomes of patients with familial PC is not described well. AIMS: This study aims to evaluate outcomes following resection in patients with familial PC. METHODS: We studied 208 patients who underwent resection of PC from 2000 to 2007 and had prospectively completed family history questionnaires for the Biospecimen Resource for Pancreas Research at our institution. We compared clinical characteristics and outcomes of familial and sporadic PC patients. RESULTS: Familial (N = 15) and sporadic PC patients (N = 193) did not have significantly different demographics, pre-operative CA19-9, pre-operative weight loss, R0 status, or T-staging (all p ≥ 0.05). Familial PC patients had lower pre-operative total serum bilirubin concentrations (p = 0.03) and lesions outside of the pancreatic head more frequently (p = 0.02) than sporadic PC patients. There was no difference in survival at 2 years between familial and sporadic PC patients (p = 0.52). CONCLUSIONS: Familial PC patients appear to develop tumors outside of the pancreatic head more frequently than sporadic PC patients. This difference in tumor distribution may be due to a broader area of cancer susceptibility within the pancreas for familial PC patients.
Authors: N Sato; C Rosty; M Jansen; N Fukushima; T Ueki; C J Yeo; J L Cameron; C A Iacobuzio-Donahue; R H Hruban; M Goggins Journal: Am J Pathol Date: 2001-12 Impact factor: 4.307
Authors: A C Tersmette; G M Petersen; G J Offerhaus; F C Falatko; K A Brune; M Goggins; E Rozenblum; R E Wilentz; C J Yeo; J L Cameron; S E Kern; R H Hruban Journal: Clin Cancer Res Date: 2001-03 Impact factor: 12.531
Authors: R E Wilentz; M Goggins; M Redston; V A Marcus; N V Adsay; T A Sohn; S S Kadkol; C J Yeo; M Choti; M Zahurak; K Johnson; M Tascilar; G J Offerhaus; R H Hruban; S E Kern Journal: Am J Pathol Date: 2000-05 Impact factor: 4.307
Authors: Theresa P Yeo; Ralph H Hruban; Jonathan Brody; Kieran Brune; Sheila Fitzgerald; Charles J Yeo Journal: J Gastrointest Surg Date: 2009-05-21 Impact factor: 3.452
Authors: Alison P Klein; Ralph H Hruban; Aatur D Singhi; Hiroyuki Ishida; Syed Z Ali; Michael Goggins; Marcia Canto; Christopher Wolfgang; Zina Meriden; Nicholas Roberts Journal: Pancreatology Date: 2015-04-23 Impact factor: 3.996