Literature DB >> 21359402

Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors.

John Spencer1, Jahangir Amin, Samantha K Callear, Graham J Tizzard, Simon J Coles, Peter Coxhead, Matthew Guille.   

Abstract

(E)- and (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-ones 1 have been structurally modified in order to explore SAR against a range of kinases. Of note is the submicromolar to low micromolar inhibition of DYRK3 and 4 by a number of complexes. Screening using Xenopus embryos showed some of the compounds to have potent antiangiogenisis activity.

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Year:  2011        PMID： 21359402     DOI： 10.1039/c1mt00017a

Source DB:  PubMed          Journal:  Metallomics        ISSN： 1756-5901            Impact factor:   4.526


  4 in total

1.  Synthesis and Biological Evaluation of JAHAs: Ferrocene-Based Histone Deacetylase Inhibitors.

Authors:  John Spencer; Jahangir Amin; Minghua Wang; Graham Packham; Sharifah S Syed Alwi; Graham J Tizzard; Simon J Coles; Ronald M Paranal; James E Bradner; Tom D Heightman
Journal:  ACS Med Chem Lett       Date:  2011-03-18       Impact factor: 4.345

2.  Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain-like Protease PLpro.

Authors:  Maria Gil-Moles; Sebastian Türck; Uttara Basu; Andrea Pettenuzzo; Saurav Bhattacharya; Ananthu Rajan; Xiang Ma; Rolf Büssing; Jessica Wölker; Hilke Burmeister; Henrik Hoffmeister; Pia Schneeberg; Andre Prause; Petra Lippmann; Josephine Kusi-Nimarko; Storm Hassell-Hart; Andrew McGown; Daniel Guest; Yan Lin; Anna Notaro; Robin Vinck; Johannes Karges; Kevin Cariou; Kun Peng; Xue Qin; Xing Wang; Joanna Skiba; Łukasz Szczupak; Konrad Kowalski; Ulrich Schatzschneider; Catherine Hemmert; Heinz Gornitzka; Elena R Milaeva; Alexey A Nazarov; Gilles Gasser; John Spencer; Luca Ronconi; Ulrich Kortz; Jindrich Cinatl; Denisa Bojkova; Ingo Ott
Journal:  Chemistry       Date:  2021-11-23       Impact factor: 5.020

3.  Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor.

Authors:  Kathrin Wähler; Katja Kräling; Holger Steuber; Eric Meggers
Journal:  ChemistryOpen       Date:  2013-09-05       Impact factor: 2.911

4.  Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety.

Authors:  Supojjanee Sansook; Cory A Ocasio; Iain J Day; Graham J Tizzard; Simon J Coles; Oleg Fedorov; James M Bennett; Jonathan M Elkins; John Spencer
Journal:  Org Biomol Chem       Date:  2017-10-18       Impact factor: 3.876
  4 in total

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