Literature DB >> 21359115

THE CASE FOR AN ETHICS RESEARCH CONSORTIUM FOR EMERGING TECHNOLOGIES: PUBLIC PERCEPTION OF STEM CELL RESEARCH AND DEVELOPMENT.

Cesar V Borlongan1, Camille McWhirter, Caroline Fultz-Carver, Kevin T Fitzgerald, Paul R Sanberg.   

Abstract

Emerging technologies have gained notoriety as a catalyst of socioeconomic progress, but have also inspired a revolution in ethics. Here, we provide an overview of ethics in stem cell-based therapies and offer a compelling argument for a need to establish an Ethics Research Consortium that will be tasked to assemble an interdisciplinary panel of experts who will apply ethical principles to analyze the social merit relative to the economic incentives of this emerging technology. Milestone studies on cell therapy in Parkinson's disease and stroke over the last two decades were the focus of this commentary. The major criterion for study selection was based on public opinion, scientific discussion, and government reactions generated by these pioneering studies. Original data from the selected studies are presented. Interpretation and discussion of data captured the prevailing views of the public and scientific community, as well as the government regulatory and oversight decisions (i.e., ban on embryonic stem cell research funding). Lessons learned from two decades of cell-based therapies indicate that poor management of the public discourse of ethics concerning emerging technologies might have contributed to misperceptions within both the public and the research community that have hindered the progress of scientific innovation and even delayed the clinical application of potentially life-saving treatments to critically ill patients. We propose the creation of a Consortium that will evaluate how these novel ethical issues in emerging technologies are addressed under current oversight and regulatory structures and where there may be gaps and need for revised or new public policy approaches.

Entities:  

Year:  2010        PMID: 21359115      PMCID: PMC3043602          DOI: 10.3727/194982410x12741230805263

Source DB:  PubMed          Journal:  Technol Innov


  15 in total

1.  Umbilical cord blood transfusions for prevention of progressive brain injury and induction of neural recovery: an immunological perspective.

Authors:  Alison E Willing; David J Eve; Paul R Sanberg
Journal:  Regen Med       Date:  2007-07       Impact factor: 3.806

Review 2.  Tissue engineering and biomaterials in regenerative medicine.

Authors:  Katherine Nolan; Yoann Millet; Camillo Ricordi; Cherie L Stabler
Journal:  Cell Transplant       Date:  2008       Impact factor: 4.064

3.  Potential of stem/progenitor cells in treating stroke: the missing steps in translating cell therapy from laboratory to clinic.

Authors:  Cesar V Borlongan; Michael Chopp; Gary K Steinberg; Tonya M Bliss; Yi Li; Mei Lu; David C Hess; Douglas Kondziolka
Journal:  Regen Med       Date:  2008-05       Impact factor: 3.806

Review 4.  Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke.

Authors:  Koichi Hara; Takao Yasuhara; Mina Maki; Noriyuki Matsukawa; Tadashi Masuda; Seong Jin Yu; Mohammed Ali; Guolong Yu; Lin Xu; Seung U Kim; David C Hess; Cesar V Borlongan
Journal:  Prog Neurobiol       Date:  2008-04-26       Impact factor: 11.685

Review 5.  Tumorigenicity issues of embryonic carcinoma-derived stem cells: relevance to surgical trials using NT2 and hNT neural cells.

Authors:  Mary B Newman; Iwona Misiuta; Alison E Willing; Tanja Zigova; Richard C Karl; Cesar V Borlongan; Paul R Sanberg
Journal:  Stem Cells Dev       Date:  2005-02       Impact factor: 3.272

6.  Transplantation of cultured human neuronal cells for patients with stroke.

Authors:  D Kondziolka; L Wechsler; S Goldstein; C Meltzer; K R Thulborn; J Gebel; P Jannetta; S DeCesare; E M Elder; M McGrogan; M A Reitman; L Bynum
Journal:  Neurology       Date:  2000-08-22       Impact factor: 9.910

7.  Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats.

Authors:  C V Borlongan; Y Tajima; J Q Trojanowski; V M Lee; P R Sanberg
Journal:  Exp Neurol       Date:  1998-02       Impact factor: 5.330

8.  Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease.

Authors:  J H Kordower; T B Freeman; B J Snow; F J Vingerhoets; E J Mufson; P R Sanberg; R A Hauser; D A Smith; G M Nauert; D P Perl
Journal:  N Engl J Med       Date:  1995-04-27       Impact factor: 91.245

Review 9.  Cell therapy for stroke: remaining issues to address before embarking on clinical trials.

Authors:  Cesar V Borlongan
Journal:  Stroke       Date:  2008-12-08       Impact factor: 7.914

10.  Long-term survival and bipotent terminal differentiation of human mesenchymal stem cells (hMSC) in combination with a commercially available three-dimensional collagen scaffold.

Authors:  S Neuss; R Stainforth; J Salber; P Schenck; M Bovi; R Knüchel; A Perez-Bouza
Journal:  Cell Transplant       Date:  2008       Impact factor: 4.064

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  4 in total

1.  Regulated and Unregulated Clinical Trials of Stem Cell Therapies for Stroke.

Authors:  Michael G Liska; Marci G Crowley; Cesar V Borlongan
Journal:  Transl Stroke Res       Date:  2017-01-26       Impact factor: 6.829

2.  Recent Advances in Stem Cell-Based Therapeutics for Stroke.

Authors:  Eleonora Napoli; Cesar V Borlongan
Journal:  Transl Stroke Res       Date:  2016-08-12       Impact factor: 6.829

3.  Review of the history and current status of cell-transplant approaches for the management of neuropathic pain.

Authors:  Mary J Eaton; Yerko Berrocal; Stacey Q Wolfe; Eva Widerström-Noga
Journal:  Pain Res Treat       Date:  2012-06-14

4.  Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury: Comparison of hNT2.17 and hNT2.19 Cell Lines.

Authors:  Mary J Eaton; Yerko Berrocal; Stacey Q Wolfe
Journal:  Pain Res Treat       Date:  2012-04-24
  4 in total

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