BACKGROUND: ABO-incompatible living unrelated donor kidney transplantation is an immunologically high-risk procedure, but few reports have been made on the outcomes of these transplants. PATIENTS AND METHODS: We analyzed 12 kidney transplants using ABO-incompatible living-unrelated donors performed at our institution between January 1999 and December 2007, focusing on the immunosuppressive protocols, complications and graft survivals. RESULTS: Patient and graft survival rates were 100%. One patient experienced antibody-mediated rejection and intractable acute cellular rejection, one had antibody-mediated rejection and one had acute cellular rejection, but their grafts survived after intensive immunosuppressive treatment. There were no severe complications among the recipients. CONCLUSIONS: In ABO-incompatible living unrelated donor kidney transplantation, severe rejections may occur due to ABO incompatibility and poor histocompatibility. Therefore, appropriate desensitization, immunosuppression and recipient care are needed for a successful transplant. Recent significant improvements in outcomes indicate that it has become a viable treatment option, given the lack of available donor organs.
BACKGROUND:ABO-incompatible living unrelated donor kidney transplantation is an immunologically high-risk procedure, but few reports have been made on the outcomes of these transplants. PATIENTS AND METHODS: We analyzed 12 kidney transplants using ABO-incompatible living-unrelated donors performed at our institution between January 1999 and December 2007, focusing on the immunosuppressive protocols, complications and graft survivals. RESULTS:Patient and graft survival rates were 100%. One patient experienced antibody-mediated rejection and intractable acute cellular rejection, one had antibody-mediated rejection and one had acute cellular rejection, but their grafts survived after intensive immunosuppressive treatment. There were no severe complications among the recipients. CONCLUSIONS: In ABO-incompatible living unrelated donor kidney transplantation, severe rejections may occur due to ABO incompatibility and poor histocompatibility. Therefore, appropriate desensitization, immunosuppression and recipient care are needed for a successful transplant. Recent significant improvements in outcomes indicate that it has become a viable treatment option, given the lack of available donor organs.
Authors: John R Montgomery; Jonathan C Berger; Daniel S Warren; Nathan T James; Robert A Montgomery; Dorry L Segev Journal: Transplantation Date: 2012-03-27 Impact factor: 4.939
Authors: Madelon van Agteren; Willem Weimar; Annelies E de Weerd; Peter A W Te Boekhorst; Jan N M Ijzermans; Jaqueline van de Wetering; Michiel G H Betjes Journal: J Transplant Date: 2014-02-06
Authors: P N Gupta; S Pokhariyal; S Bansal; S Jain; V Saxena; R Sharma; M Jain; P Jha; S K Sethi; P Ghosh; A Tewari; R Ahlawat; V Kher Journal: Indian J Nephrol Date: 2013-05