Literature DB >> 21357383

No association of risk variants for diabetes and obesity with breast cancer: the Multiethnic Cohort and PAGE studies.

Fang Chen1, Lynne R Wilkens, Kristine R Monroe, Daniel O Stram, Laurence N Kolonel, Brian E Henderson, Loïc Le Marchand, Christopher A Haiman.   

Abstract

BACKGROUND: Body mass index is an established risk factor for postmenopausal breast cancer. Epidemiologic studies have also reported a positive association between type 2 diabetes (T2D) and breast cancer risk.
METHODS: To investigate a genetic basis linking these common phenotypes with breast cancer, we tested 31 common variants for T2D and obesity in a case-control study of 1,915 breast cancer cases and 2,884 controls nested within the Multiethnic Cohort (MEC) study.
RESULTS: Following adjustment for multiple tests, we found no significant association between any variant and breast cancer risk. Summary scores comprising the numbers of risk alleles for T2D and/or obesity were also not found to be significantly associated with breast cancer risk.
CONCLUSIONS: Our findings provide no evidence for association between established T2D and/or obesity risk variants and breast cancer risk among women of various ethnicities. IMPACT: These results suggest that the potential for a shared biology between T2D/obesity and breast cancer is not due to pleiotropic effects of these risk variants. ©2011 AACR.

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Year:  2011        PMID： 21357383      PMCID： PMC4201112          DOI： 10.1158/1055-9965.EPI-11-0135

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  15 in total

Review 1.  Breast cancer and diabetes mellitus.

Authors:  S Schott; A Schneeweiss; C Sohn
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Review 2.  Western nutrition and the insulin resistance syndrome: a link to breast cancer.

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3.  Allelic discrimination by nick-translation PCR with fluorogenic probes.

Authors:  L G Lee; C R Connell; W Bloch
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4.  Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States).

Authors:  Libby M Morimoto; Emily White; Z Chen; Rowan T Chlebowski; Jennifer Hays; Lewis Kuller; Ana Marie Lopez; JoAnn Manson; Karen L Margolis; Paola C Muti; Marcia L Stefanick; Anne McTiernan
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Review 5.  Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence.

Authors:  Rudolf Kaaks
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6.  A multiethnic cohort in Hawaii and Los Angeles: baseline characteristics.

Authors:  L N Kolonel; B E Henderson; J H Hankin; A M Nomura; L R Wilkens; M C Pike; D O Stram; K R Monroe; M E Earle; F S Nagamine
Journal:  Am J Epidemiol       Date:  2000-02-15       Impact factor: 4.897

Review 7.  Nutrition, hormones, and breast cancer: is insulin the missing link?

Authors:  R Kaaks
Journal:  Cancer Causes Control       Date:  1996-11       Impact factor: 2.506

Review 8.  Overweight, obesity, and cancer risk.

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Review 9.  Diabetes, metabolic syndrome, and breast cancer: a review of the current evidence.

Authors:  Fei Xue; Karin B Michels
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10.  Serum C-peptide levels and breast cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC).

Authors:  Martijn Verheus; Petra H M Peeters; Sabina Rinaldi; Laure Dossus; Carine Biessy; Anja Olsen; Anne Tjønneland; Kim Overvad; Majbritt Jeppesen; Françoise Clavel-Chapelon; Bertrand Téhard; Gabriele Nagel; Jakob Linseisen; Heiner Boeing; Petra H Lahmann; Athina Arvaniti; Theodora Psaltopoulou; Antonia Trichopoulou; Domenico Palli; Rosario Tumino; Salvatore Panico; Carlotta Sacerdote; Sabina Sieri; Carla H van Gils; Bas H Bueno-de-Mesquita; Carlos A González; Eva Ardanaz; Nera Larranaga; Carmen Martinez Garcia; Carmen Navarro; J Ramón Quirós; Tim Key; Naomi Allen; Sheila Bingham; Kay-Tee Khaw; Nadia Slimani; Elio Riboli; Rudolf Kaaks
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Review 1.  Cell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentials.

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2.  Genetic variation in peroxisome proliferator-activated receptor gamma, soy, and mammographic density in Singapore Chinese women.

Authors:  Eunjung Lee; Chris Hsu; David Van den Berg; Giske Ursin; Woon-Puay Koh; Jian-Min Yuan; Daniel O Stram; Mimi C Yu; Anna H Wu
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2012-02-01       Impact factor: 4.254

3.  Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry.

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Journal:  Cancer Causes Control       Date:  2016-04-06       Impact factor: 2.506

4.  The Association Between Body Size and Breast Cancer in Han Women in Northern and Eastern China.

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Journal:  Oncologist       Date:  2016-08-05

5.  Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry.

Authors:  Ningqi Hou; Yonglan Zheng; Eric R Gamazon; Temidayo O Ogundiran; Clement Adebamowo; Katherine L Nathanson; Susan M Domchek; Timothy R Rebbeck; Michael S Simon; Esther M John; Anselm Hennis; Barbara Nemesure; Suh-Yuh Wu; M Cristina Leske; Stefan Ambs; Qun Niu; Jing Zhang; Brandon Pierce; Nancy J Cox; Olufunmilayo I Olopade; Dezheng Huo
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2012-01-11       Impact factor: 4.254

6.  Genetic polymorphisms of diabetes-related genes, their interaction with diabetes status, and breast cancer incidence and mortality: The Long Island Breast Cancer Study Project.

Authors:  Humberto Parada; Rebecca J Cleveland; Kari E North; June Stevens; Susan L Teitelbaum; Alfred I Neugut; Regina M Santella; Maria E Martinez; Marilie D Gammon
Journal:  Mol Carcinog       Date:  2018-12-11       Impact factor: 4.784

7.  Reproductive aging-associated common genetic variants and the risk of breast cancer.

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Journal:  Breast Cancer Res       Date:  2012-03-20       Impact factor: 6.466

8.  Obesity, diabetes mellitus, and the risk of female breast cancer in Eastern China.

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9.  Joint Effect of Genotypic and Phenotypic Features of Reproductive Factors on Endometrial Cancer Risk.

Authors:  Zhanwei Wang; Harvey Risch; Lingeng Lu; Melinda L Irwin; Susan Mayne; Peter Schwartz; Thomas Rutherford; Immaculata De Vivo; Herbert Yu
Journal:  Sci Rep       Date:  2015-10-26       Impact factor: 4.379
  9 in total

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