Literature DB >> 21356345

Signaling mechanism of poly(ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases.

Xueqing Ba1, Nisha Jain Garg.   

Abstract

Poly(ADP-ribosyl)ation, attaching the ADP-ribose polymer chain to the receptor protein, is a unique posttranslational modification. Poly(ADP-ribose) polymerase-1 (PARP-1) is a well-characterized member of the PARP family. In this review, we provide a general update on molecular structure and structure-based activity of this enzyme. However, we mainly focus on the roles of PARP-1 in inflammatory diseases. Specifically, we discuss the signaling pathway context that PARP-1 is involved in to regulate the pathogenesis of inflammation. PARP-1 facilitates diverse inflammatory responses by promoting inflammation-relevant gene expression, such as cytokines, oxidation-reduction-related enzymes, and adhesion molecules. Excessive activation of PARP-1 induces mitochondria-associated cell death in injured tissues and constitutes another mechanism for exacerbating inflammation.
Copyright © 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21356345      PMCID： PMC3069822          DOI： 10.1016/j.ajpath.2010.12.004

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  125 in total

1.  Poly(ADP-ribose) polymerase-1 modulates interferon-gamma-inducible protein (IP)-10 expression in murine embryonic fibroblasts by stabilizing IP-10 mRNA.

Authors:  Marisa Galbis-Martínez; Luis Saenz; Pablo Ramírez; Pascual Parrilla; José Yélamos
Journal:  Mol Immunol       Date:  2010-02-19       Impact factor: 4.407

Review 2.  Apoptosis-inducing factor: vital and lethal.

Authors:  Nazanine Modjtahedi; Fabrizio Giordanetto; Frank Madeo; Guido Kroemer
Journal:  Trends Cell Biol       Date:  2006-04-18       Impact factor: 20.808

3.  Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2.

Authors:  Tiina M Kauppinen; Wai Y Chan; Sang Won Suh; Amanda K Wiggins; Eric J Huang; Raymond A Swanson
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-20       Impact factor: 11.205

4.  Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.

Authors:  Paul O Hassa; Sandra S Haenni; Christine Buerki; Nadja I Meier; William S Lane; Heather Owen; Monika Gersbach; Ralph Imhof; Michael O Hottiger
Journal:  J Biol Chem       Date:  2005-10-04       Impact factor: 5.157

5.  NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death.

Authors:  Conrad C Alano; Philippe Garnier; Weihai Ying; Youichirou Higashi; Tiina M Kauppinen; Raymond A Swanson
Journal:  J Neurosci       Date:  2010-02-24       Impact factor: 6.167

6.  Trypanosoma cruzi induces the reactive oxygen species-PARP-1-RelA pathway for up-regulation of cytokine expression in cardiomyocytes.

Authors:  Xueqing Ba; Shivali Gupta; Mercy Davidson; Nisha Jain Garg
Journal:  J Biol Chem       Date:  2010-02-09       Impact factor: 5.157

7.  Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation.

Authors:  Yue Xu; Shuang Huang; Zheng-Gang Liu; Jiahuai Han
Journal:  J Biol Chem       Date:  2006-01-30       Impact factor: 5.157

8.  Nitric oxide-dependent negative feedback of PARP-1 trans-activation of the inducible nitric-oxide synthase gene.

Authors:  Zhiyuan Yu; Teresa Kuncewicz; William P Dubinsky; Bruce C Kone
Journal:  J Biol Chem       Date:  2006-02-07       Impact factor: 5.157

9.  Effects of PARP-1 deficiency on airway inflammatory cell recruitment in response to LPS or TNF: differential effects on CXCR2 ligands and Duffy Antigen Receptor for Chemokines.

Authors:  Mourad Zerfaoui; Amarjit S Naura; Youssef Errami; Chetan P Hans; Bashir M Rezk; Jiwon Park; Waleed Elsegeiny; Hogyoung Kim; Kevin Lord; Jong G Kim; A Hamid Boulares
Journal:  J Leukoc Biol       Date:  2009-09-10       Impact factor: 4.962

10.  Poly (ADP-ribose) polymerase-1 initiated neuronal cell death pathway--do androgens matter?

Authors:  K Vagnerova; K Liu; A Ardeshiri; J Cheng; S J Murphy; P D Hurn; P S Herson
Journal:  Neuroscience       Date:  2009-12-24       Impact factor: 3.590
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  66 in total

1.  The clinically used PARP inhibitor olaparib improves organ function, suppresses inflammatory responses and accelerates wound healing in a murine model of third-degree burn injury.

Authors:  Akbar Ahmad; Gabor Olah; David N Herndon; Csaba Szabo
Journal:  Br J Pharmacol       Date:  2017-03-05       Impact factor: 8.739

Review 2.  Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases.

Authors:  Nathan A Berger; Valerie C Besson; A Hamid Boulares; Alexander Bürkle; Alberto Chiarugi; Robert S Clark; Nicola J Curtin; Salvatore Cuzzocrea; Ted M Dawson; Valina L Dawson; György Haskó; Lucas Liaudet; Flavio Moroni; Pál Pacher; Peter Radermacher; Andrew L Salzman; Solomon H Snyder; Francisco Garcia Soriano; Robert P Strosznajder; Balázs Sümegi; Raymond A Swanson; Csaba Szabo
Journal:  Br J Pharmacol       Date:  2017-03-26       Impact factor: 8.739

3.  Daidzein suppresses pro-inflammatory chemokine Cxcl2 transcription in TNF-α-stimulated murine lung epithelial cells via depressing PARP-1 activity.

Authors:  Hai-yan Li; Lang Pan; Yue-shuang Ke; Enkhzaya Batnasan; Xiang-qun Jin; Zhong-ying Liu; Xue-qing Ba
Journal:  Acta Pharmacol Sin       Date:  2014-03-17       Impact factor: 6.150

4.  Negative transcriptional regulation of inflammatory genes by group B3 vitamin nicotinamide.

Authors:  Xiao-Ming Zhang; Yu-Ping Jing; Meng-Ying Jia; Li Zhang
Journal:  Mol Biol Rep       Date:  2012-10-07       Impact factor: 2.316

5.  Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors.

Authors:  Elisabet Wahlberg; Tobias Karlberg; Ekaterina Kouznetsova; Natalia Markova; Antonio Macchiarulo; Ann-Gerd Thorsell; Ewa Pol; Åsa Frostell; Torun Ekblad; Delal Öncü; Björn Kull; Graeme Michael Robertson; Roberto Pellicciari; Herwig Schüler; Johan Weigelt
Journal:  Nat Biotechnol       Date:  2012-02-19       Impact factor: 54.908

6.  Contribution of poly(ADP-ribose)polymerase-1 activation and apoptosis in trichloroethene-mediated autoimmunity.

Authors:  Gangduo Wang; Huaxian Ma; Jianling Wang; M Firoze Khan
Journal:  Toxicol Appl Pharmacol       Date:  2018-10-10       Impact factor: 4.219

7.  Macrophages Promote Oxidative Metabolism To Drive Nitric Oxide Generation in Response to Trypanosoma cruzi.

Authors:  Sue-Jie Koo; Imran H Chowdhury; Bartosz Szczesny; Xianxiu Wan; Nisha J Garg
Journal:  Infect Immun       Date:  2016-11-18       Impact factor: 3.441

8.  Charon Mediates Immune Deficiency-Driven PARP-1-Dependent Immune Responses in Drosophila.

Authors:  Yingbiao Ji; Colin Thomas; Nikita Tulin; Niraj Lodhi; Ernest Boamah; Vladimir Kolenko; Alexei V Tulin
Journal:  J Immunol       Date:  2016-08-15       Impact factor: 5.422

Review 9.  Therapeutic applications of PARP inhibitors: anticancer therapy and beyond.

Authors:  Nicola J Curtin; Csaba Szabo
Journal:  Mol Aspects Med       Date:  2013-01-29

10.  Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment.

Authors:  K Nho; J J Corneveaux; S Kim; H Lin; S L Risacher; L Shen; S Swaminathan; V K Ramanan; Y Liu; T Foroud; M H Inlow; A L Siniard; R A Reiman; P S Aisen; R C Petersen; R C Green; C R Jack; M W Weiner; C T Baldwin; K Lunetta; L A Farrer; S J Furney; S Lovestone; A Simmons; P Mecocci; B Vellas; M Tsolaki; I Kloszewska; H Soininen; B C McDonald; M R Farlow; B Ghetti; M J Huentelman; A J Saykin
Journal:  Mol Psychiatry       Date:  2013-04-23       Impact factor: 15.992
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