| Literature DB >> 21356283 |
Cunxian Duan1, Dianrui Zhang, Feihu Wang, Dandan Zheng, Lejiao Jia, Feifei Feng, Yue Liu, Yancai Wang, Keli Tian, Fengshan Wang, Qiang Zhang.
Abstract
The principle objective of this research was to develop and characterize pH-responsive and biocompatible nanogels as a tumor-targeting drug delivery system. The nanogels were self-assembled from chitosan-based copolymers, chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAm). The copolymers were synthesized via free radical copolymerization and characterized for their chemical structure by FT-IR and (1)H NMR. These copolymers could be efficiently loaded with oridonin (ORI) and the characteristics of ORI-loaded nanogels were evaluated. Drug release researches indicated that the ORI-loaded nanogels displayed pH-dependent release behaviors. Based on MTT assay and cellular morphological analysis, the anti-tumor activity of ORI-loaded nanogels was higher at pH 6.5 than at pH 7.4. In conclusion, the obtained nanogels appeared to be of great promise in tumor extracellular pH targeting for ORI.Entities:
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Year: 2011 PMID： 21356283 DOI： 10.1016/j.ijpharm.2011.02.050
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875