Literature DB >> 21356279

Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts.

Po Yee Chiu1, Philip Y Lam, Chung Wai Yan, Kam Ming Ko.   

Abstract

The effects of schisandrin B (Sch B) and its analogs on solar irradiation-induced oxidative injury were examined in BJ human fibroblasts. Sch B and schisandrin C (Sch C) increased cellular reduced glutathione (GSH) level and protected against solar irradiation-induced oxidative injury. The photoprotection was paralleled by decreases in the elastases-type protease activity and matrix-metalloproteinases-1 expression in solar-irradiated fibroblasts. The cytochrome P-450-mediated metabolism of Sch B or Sch C caused ROS production. The results suggest that by virtue of its pro-oxidant action and the subsequent glutathione antioxidant response, Sch B or Sch C may offer the prospect of preventing skin photo-aging.
Copyright © 2011 Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21356279     DOI： 10.1016/j.fitote.2011.02.010

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  9 in total

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Authors:  Zheng-Fei Yan; Yang Yang; Feng-Hua Tian; Xin-Xin Mao; Yu Li; Chang-Tian Li
Journal:  Evid Based Complement Alternat Med       Date:  2014-08-13       Impact factor: 2.629

8.  The Scientific Basis and Advantage of Human Experiential Assessment in the quality control of Chinese Herbal Medicines exampling as Schisandrae Chinensis Fructus.

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Journal:  Sci Rep       Date:  2018-04-09       Impact factor: 4.379

9.  Schisandrin B regulates MC3T3-E1 subclone 14 cells proliferation and differentiation through BMP2-SMADs-RUNX2-SP7 signaling axis.

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Journal:  Sci Rep       Date:  2020-09-02       Impact factor: 4.379
  9 in total

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