Literature DB >> 21355865

HLA-C as a mediator of natural killer and T-cell activation: spectator or key player?

Marie-Eve Blais1, Tao Dong, Sarah Rowland-Jones.   

Abstract

The biochemical properties of the HLA-C antigen differ substantially from those of HLA-A and -B molecules. For this reason, HLA-C diversity and expression at the cell surface are much lower than its counterparts and in consequence HLA-C-restricted responses have been infrequently detected and described. In this review we summarise the key differences between HLA-C and other class I molecules and provide an update on natural killer and T-cell responses restricted by HLA-C. We also discuss the different clinical settings associated with HLA-C alleles which mainly consist of autoimmune disorders, cancers and chronic infections.
© 2011 The Authors. Immunology © 2011 Blackwell Publishing Ltd.

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Year:  2011        PMID: 21355865      PMCID: PMC3088962          DOI: 10.1111/j.1365-2567.2011.03422.x

Source DB:  PubMed          Journal:  Immunology        ISSN: 0019-2805            Impact factor:   7.397


  48 in total

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2.  Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand.

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Authors:  Q R Fan; E O Long; D C Wiley
Journal:  Nat Immunol       Date:  2001-05       Impact factor: 25.606

4.  A single bottleneck in HLA-C assembly.

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5.  Sequence-based typing provides a new look at HLA-C diversity.

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6.  Potential underestimation of HLA-C-restricted cytotoxic T-lymphocyte responses.

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7.  Nef interference with HIV-1-specific CTL antiviral activity is epitope specific.

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  43 in total

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Journal:  J Clin Diagn Res       Date:  2015-09-01

2.  High frequency of HIV mutations associated with HLA-C suggests enhanced HLA-C-restricted CTL selective pressure associated with an AIDS-protective polymorphism.

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5.  Immunogenomic correlates of response to cetuximab monotherapy in head and neck squamous cell carcinoma.

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Review 6.  The emerging role of HLA-C in HIV-1 infection.

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7.  The molecular basis for peptide repertoire selection in the human leucocyte antigen (HLA) C*06:02 molecule.

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8.  Immunoprevalence and immunodominance of HLA-Cw*0801-restricted T cell response targeting the hepatitis B virus envelope transmembrane region.

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9.  Decidual T Cells Exhibit a Highly Differentiated Phenotype and Demonstrate Potential Fetal Specificity and a Strong Transcriptional Response to IFN.

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10.  An Immunoinformatics Approach for SARS-CoV-2 in Latam Populations and Multi-Epitope Vaccine Candidate Directed towards the World's Population.

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