| Literature DB >> 21355865 |
Marie-Eve Blais1, Tao Dong, Sarah Rowland-Jones.
Abstract
The biochemical properties of the HLA-C antigen differ substantially from those of HLA-A and -B molecules. For this reason, HLA-C diversity and expression at the cell surface are much lower than its counterparts and in consequence HLA-C-restricted responses have been infrequently detected and described. In this review we summarise the key differences between HLA-C and other class I molecules and provide an update on natural killer and T-cell responses restricted by HLA-C. We also discuss the different clinical settings associated with HLA-C alleles which mainly consist of autoimmune disorders, cancers and chronic infections.Entities:
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Year: 2011 PMID: 21355865 PMCID: PMC3088962 DOI: 10.1111/j.1365-2567.2011.03422.x
Source DB: PubMed Journal: Immunology ISSN: 0019-2805 Impact factor: 7.397