| Literature DB >> 21354146 |
Florence Brellier1, Katrin Hostettler, Hans-Rudolf Hotz, Ceyda Ozcakir, Sedat A Çöloğlu, Dieudonnée Togbe, Bernard Ryffel, Michael Roth, Ruth Chiquet-Ehrismann.
Abstract
We explored novel functions of tenascin-C by comparing mouse embryonic fibroblasts (MEFs) proficient or deficient in tenascin-C expression. Transcript profiling analysis identified tissue plasminogen activator (tPA) as the most consistently over-expressed gene in all tenascin-C deficient MEFs. This was confirmed by real-time PCR as well as by protein expression analysis. In agreement with these observations, tenascin-C deficient MEFs had an increased capacity to digest fibrin in situ. Consistently, tenascin-C expression in vivo was found to correlate with fibrin deposition in several diseases associated with tenascin-C overexpression such as fibrosis, asthma and cancer. In conclusion, the present study suggests a new role of tenascin-C as a regulator of the fibrinolytic system.Entities:
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Year: 2011 PMID： 21354146 DOI： 10.1016/j.febslet.2011.02.023
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124