Literature DB >> 21353775

A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis.

Yu-Ming Chung1, Fang-Rong Chang, Tseng-Fu Tseng, Tsong-Long Hwang, Lei-Chin Chen, Shou-Fang Wu, Chia-Lin Lee, Zu-Yau Lin, Li-Yeh Chuang, Jinu-Huang Su, Yang-Chang Wu.   

Abstract

A novel alkaloid, aristopyridinone A (1) and a new phenanthrene, aristolamide II (2), were isolated from Aristolochia manshuriensis (Guanmutong) together with eight known phenanthrenes (3-10). All structures were elucidated by spectroscopic methods. Compound 2 showed a selective inhibitory effect on elastase release by human neutrophils in response to fMLP with an IC(50) value of 4.11 μg/mL. Compound 7 exhibited significant inhibitory effects on superoxide anion generation and elastase release with IC(50) values of 0.12 and 0.20 μg/mL, respectively.
Copyright © 2011. Published by Elsevier Ltd.

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Year:  2011        PMID： 21353775     DOI： 10.1016/j.bmcl.2011.01.067

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

Review 1.  Antagonism of human formyl peptide receptor 1 with natural compounds and their synthetic derivatives.

Authors:  Igor A Schepetkin; Andrei I Khlebnikov; Liliya N Kirpotina; Mark T Quinn
Journal:  Int Immunopharmacol       Date:  2015-09-15       Impact factor: 4.932

2.  3,4- and 3,5-Disubstituted 2-Pyridones Using an Intermolecular Cycloaddition / Cycloreversion Strategy: Toward the Synthesis of Aristopyridinone A.

Authors:  Maren K Leibowitz; Ethan S Winter; Jonathan R Scheerer
Journal:  Tetrahedron Lett       Date:  2015-10-28       Impact factor: 2.415

Review 3.  Chemical Constituents and Pharmacology of the Aristolochia ( mădōu ling) species.

Authors:  Ping-Chung Kuo; Yue-Chiun Li; Tian-Shung Wu
Journal:  J Tradit Complement Med       Date:  2012-10

4.  Isolation and structural characterization of bioactive compound from Aristolochia sprucei aqueous extract with anti-myotoxic activity.

Authors:  Isela I González Rodríguez; Aleff F Francisco; Leandro S Moreira-Dill; Aristides Quintero; César L S Guimarães; Carlos A H Fernandes; Agnes A S Takeda; Fernando B Zanchi; Cléopatra A S Caldeira; Paulo S Pereira; Marcos R M Fontes; Juliana P Zuliani; Andreimar M Soares
Journal:  Toxicon X       Date:  2020-06-20

5.  Study of the anti-allergic and anti-inflammatory activity of Brachychiton rupestris and Brachychiton discolor leaves (Malvaceae) using in vitro models.

Authors:  Amany A Thabet; Fadia S Youssef; Michal Korinek; Fang-Rong Chang; Yang-Chang Wu; Bing-Hung Chen; Mohamed El-Shazly; Abdel Nasser B Singab; Tsong-Long Hwang
Journal:  BMC Complement Altern Med       Date:  2018-11-09       Impact factor: 3.659

Review 6.  Biological Activities of Organic Extracts of the Genus Aristolochia: A Review from 2005 to 2021.

Authors:  Martín A Lerma-Herrera; Lidia Beiza-Granados; Alejandra Ochoa-Zarzosa; Joel E López-Meza; Pedro Navarro-Santos; Rafael Herrera-Bucio; Judit Aviña-Verduzco; Hugo A García-Gutiérrez
Journal:  Molecules       Date:  2022-06-20       Impact factor: 4.927

7.  Anti-Allergic, Anti-Inflammatory and Anti-Hyperglycemic Activity of Chasmanthe aethiopica Leaf Extract and Its Profiling Using LC/MS and GLC/MS.

Authors:  Iriny M Ayoub; Michal Korinek; Mohamed El-Shazly; Bernhard Wetterauer; Hesham A El-Beshbishy; Tsong-Long Hwang; Bing-Hung Chen; Fang-Rong Chang; Michael Wink; Abdel Nasser B Singab; Fadia S Youssef
Journal:  Plants (Basel)       Date:  2021-05-31

8.  In Vitro and In Vivo Genotoxicity Assessment of Aristolochia manshuriensis Kom.

Authors:  Youn-Hwan Hwang; Taesoo Kim; Won-Kyung Cho; Hye Jin Yang; Dong Hoon Kwak; Hyunil Ha; Kwang Hoon Song; Jin Yeul Ma
Journal:  Evid Based Complement Alternat Med       Date:  2012-07-11       Impact factor: 2.629
  8 in total

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