BACKGROUND: The transmission routes of PARV4 are not completely understood. The first PARV4 serological study suggested that PARV4 is transmitted predominantly through parenteral route. OBJECTIVES: To set up an immunoblot system for studying the epidemiology of PARV4 infection in HIV-1 infected patients in Taiwan. STUDY DESIGN: Recombinant fusion proteins SUMOVP2 (a.a. 272-630 of PARV4 open reading frame 2) and SUMOVP3 (a.a. 604-914) were made and used as antigens in immunoblot. Plasma samples were from HIV-1 infected intravenous drug users IDU (69), homosexuals (66) and heterosexuals (68). RESULTS: PARV4 IgG seropositive rate was 73.9%, 71.2% and 58.8%; IgM seropositive rate was 40.5%, 16.7% and 17.6% in IDUs, homosexuals and heterosexuals, respectively. Longitudinal samples were available from two homosexuals positive for IgM anti-PARV4, persistent IgM response was found over a period of 9 and 21 months, respectively. CONCLUSIONS: PARV4 is a common viral infection in HIV-1 infected homosexuals and heterosexuals in Taiwan. The detection of IgM anti-PARV4 does not always suggest recent PARV4 infection.
BACKGROUND: The transmission routes of PARV4 are not completely understood. The first PARV4 serological study suggested that PARV4 is transmitted predominantly through parenteral route. OBJECTIVES: To set up an immunoblot system for studying the epidemiology of PARV4 infection in HIV-1 infectedpatients in Taiwan. STUDY DESIGN: Recombinant fusion proteins SUMOVP2 (a.a. 272-630 of PARV4 open reading frame 2) and SUMOVP3 (a.a. 604-914) were made and used as antigens in immunoblot. Plasma samples were from HIV-1 infected intravenous drug users IDU (69), homosexuals (66) and heterosexuals (68). RESULTS: PARV4 IgG seropositive rate was 73.9%, 71.2% and 58.8%; IgM seropositive rate was 40.5%, 16.7% and 17.6% in IDUs, homosexuals and heterosexuals, respectively. Longitudinal samples were available from two homosexuals positive for IgM anti-PARV4, persistent IgM response was found over a period of 9 and 21 months, respectively. CONCLUSIONS: PARV4 is a common viral infection in HIV-1 infected homosexuals and heterosexuals in Taiwan. The detection of IgM anti-PARV4 does not always suggest recent PARV4 infection.
Authors: Tung G Phan; Nguyen P Vo; Isidore J O Bonkoungou; Amit Kapoor; Nicolas Barro; Miguel O'Ryan; Beatrix Kapusinszky; Chunling Wang; Eric Delwart Journal: J Virol Date: 2012-08-01 Impact factor: 5.103
Authors: Jan Felix Drexler; Ulrike Reber; Doreen Muth; Petra Herzog; Augustina Annan; Fabian Ebach; Nimarko Sarpong; Samuel Acquah; Julia Adlkofer; Yaw Adu-Sarkodie; Marcus Panning; Egbert Tannich; Jürgen May; Christian Drosten; Anna Maria Eis-Hübinger Journal: Emerg Infect Dis Date: 2012-10 Impact factor: 6.883
Authors: Herman Tse; Hoi-Wah Tsoi; Jade L L Teng; Xin-Chun Chen; Haiying Liu; Boping Zhou; Bo-Jian Zheng; Patrick C Y Woo; Susanna K P Lau; Kwok-Yung Yuen Journal: PLoS One Date: 2011-09-27 Impact factor: 3.240
Authors: Ruth Simmons; Colin Sharp; Jordana Levine; Paul Bowness; Peter Simmonds; Andrea Cox; Paul Klenerman Journal: J Virol Date: 2013-01-02 Impact factor: 5.103