AIM: To examine the relationship between cognitive deterioration and the duration of untreated psychosis (DUP) in a first-episode psychosis sample. METHOD: We assessed a consecutive sample of first-episode psychosis participants (N = 50) with measures of cognitive deterioration and DUP. RESULTS: Using correlations and stepwise linear regressions, we found strong relationships between DUP and measures of cognitive deterioration. CONCLUSIONS: The length of DUP predicted cognitive deterioration. These results highlight a potential DUP grace period (>6 months) in which significant cognitive deterioration may be averted.
AIM: To examine the relationship between cognitive deterioration and the duration of untreated psychosis (DUP) in a first-episode psychosis sample. METHOD: We assessed a consecutive sample of first-episode psychosisparticipants (N = 50) with measures of cognitive deterioration and DUP. RESULTS: Using correlations and stepwise linear regressions, we found strong relationships between DUP and measures of cognitive deterioration. CONCLUSIONS: The length of DUP predicted cognitive deterioration. These results highlight a potential DUP grace period (>6 months) in which significant cognitive deterioration may be averted.
Authors: Deepak K Sarpal; Delbert G Robinson; Christina Fales; Todd Lencz; Miklos Argyelan; Katherine H Karlsgodt; Juan A Gallego; Majnu John; John M Kane; Philip R Szeszko; Anil K Malhotra Journal: Neuropsychopharmacology Date: 2017-03-15 Impact factor: 7.853