Literature DB >> 21351490

[Synthesis and HIV-1 inhibitory activity of natural products isolated from Gnetum parvifolium and their analogues].

Zhi-song Piao1, Ya-bing Feng, Lin Wang, Xing-quan Zhang, Mao Lin.   

Abstract

Resveratrol, isorhapontigenin and pinosylvin, isolated from Gnetum parvifolium, and their analogues have been synthesized and tested for their inhibitory activity of HIV-1. Natural product 12a and analogues (12d, 12e, 12g) display significant inhibitory activity of HIV-1 replication. Among them, compound 12d (trans-3, 4, 5, 4'-tetrahydroxystilbene) exhibits the most potent anti-HIV-1 activity with an IC50 value of 1.84 micromol x L(-1).

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Year:  2010        PMID： 21351490

Source DB:  PubMed          Journal:  Yao Xue Xue Bao        ISSN： 0513-4870


  2 in total

1.  Active Components from Cassia abbreviata Prevent HIV-1 Entry by Distinct Mechanisms of Action.

Authors:  Yue Zheng; Xian-Wen Yang; Dominique Schols; Mattia Mori; Bruno Botta; Andy Chevigné; Martin Mulinge; André Steinmetz; Jean-Claude Schmit; Carole Seguin-Devaux
Journal:  Int J Mol Sci       Date:  2021-05-10       Impact factor: 5.923

2.  Transcriptome Characterization of Gnetum parvifolium Reveals Candidate Genes Involved in Important Secondary Metabolic Pathways of Flavonoids and Stilbenoids.

Authors:  Nan Deng; Ermei Chang; Minghe Li; Jing Ji; Xiamei Yao; Igor V Bartish; Jianfeng Liu; Jing Ma; Lanzhen Chen; Zeping Jiang; Shengqing Shi
Journal:  Front Plant Sci       Date:  2016-03-04       Impact factor: 5.753
  2 in total

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