Literature DB >> 21351485

[Network pharmacology: new guidelines for drug discovery].

Ai-lin Liu1, Guan-hua Du.   

Abstract

The development of new drug is not only the main driving force for the development of pharmaceutical industry, but also plays a very important role in the social development. However, with the increasing demands, new drug development is facing great difficulties in recent years. The hypothesis of highly selective single-target is meeting the challenges because of its limitations. Network pharmacology has been one of the new strategies for new drug discovery based on single-target drug research in recent years. This paper focused on the basis of network pharmacology and its research progress, discussed its development direction and application prospects, and analyzed its limitations and problems as well. The application of network pharmacology in new drug development is discussed by comparing its guidelines with those of traditional Chinese medicine theory and Effective Components Group hypothesis of Chinese medicines.

Mesh:

Year:  2010        PMID: 21351485

Source DB:  PubMed          Journal:  Yao Xue Xue Bao        ISSN: 0513-4870


  11 in total

1.  A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility.

Authors:  Huiping Liu; Liuting Zeng; Kailin Yang; Guomin Zhang
Journal:  Evid Based Complement Alternat Med       Date:  2016-12-18       Impact factor: 2.629

2.  Identification of the active compounds and significant pathways of yinchenhao decoction based on network pharmacology.

Authors:  Jihan Huang; Fan Cheung; Hor-Yue Tan; Ming Hong; Ning Wang; Juan Yang; Yibin Feng; Qingshan Zheng
Journal:  Mol Med Rep       Date:  2017-08-02       Impact factor: 2.952

3.  Network Pharmacology-Based Approach to Investigate the Analgesic Efficacy and Molecular Targets of Xuangui Dropping Pill for Treating Primary Dysmenorrhea.

Authors:  Jihan Huang; Lei Li; Fan Cheung; Ning Wang; Yunfei Li; Zhenyu Fan; Fang Yin; Juan Yang; Rui Gao; Yingchun He; Yibin Feng
Journal:  Evid Based Complement Alternat Med       Date:  2017-10-08       Impact factor: 2.629

4.  A network pharmacology approach to investigate the pharmacological effects of Guizhi Fuling Wan on uterine fibroids.

Authors:  Liuting Zeng; Kailin Yang; Huiping Liu; Guomin Zhang
Journal:  Exp Ther Med       Date:  2017-09-21       Impact factor: 2.447

5.  Anti-Alzheimer's Disease Molecular Mechanism of Acori Tatarinowii Rhizoma Based on Network Pharmacology.

Authors:  Yujia Zhang; Yangshen Wu; Yunbo Fu; Luning Lin; Yiyou Lin; Yehui Zhang; Liting Ji; Changyu Li
Journal:  Med Sci Monit Basic Res       Date:  2020-06-01

6.  A network pharmacology approach to explore active compounds and pharmacological mechanisms of epimedium for treatment of premature ovarian insufficiency.

Authors:  Huishan Zhao; Yinghua Shan; Zhi Ma; Mingwei Yu; Benjiao Gong
Journal:  Drug Des Devel Ther       Date:  2019-08-22       Impact factor: 4.162

7.  Integrated Analyses Identify Immune-Related Signature Associated with Qingyihuaji Formula for Treatment of Pancreatic Ductal Adenocarcinoma Using Network Pharmacology and Weighted Gene Co-Expression Network.

Authors:  Xiang Qian; Zhuo Chen; Sha Sha Chen; Lu Ming Liu; Ai Qin Zhang
Journal:  J Immunol Res       Date:  2020-05-20       Impact factor: 4.818

Review 8.  Applications of Network Pharmacology in Traditional Chinese Medicine Research.

Authors:  Zhuchen Zhou; Bing Chen; Simiao Chen; Minqiu Lin; Ying Chen; Shan Jin; Weiyan Chen; Yuyan Zhang
Journal:  Evid Based Complement Alternat Med       Date:  2020-02-14       Impact factor: 2.629

9.  Identified the Synergistic Mechanism of Drynariae Rhizoma for Treating Fracture Based on Network Pharmacology.

Authors:  Haixiong Lin; Xiaotong Wang; Ligang Wang; Hang Dong; Peizhen Huang; Qunbin Cai; Yingjie Mo; Feng Huang; Ziwei Jiang
Journal:  Evid Based Complement Alternat Med       Date:  2019-10-20       Impact factor: 2.629

10.  Orthogonal Stimulus-Response as a Tool to Formulate Traditional Chinese Medicinal Herbal Combination: - New Scientific-Based TCM Herbal Formulating Method.

Authors:  Yean Chun Loh; Chu Shan Tan; Mun Fei Yam; Chuan Wei Oo; Wan Maznah Wan Omar
Journal:  J Pharmacopuncture       Date:  2018-09-30
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