OBJECTIVE: We explored whether prior findings of reduction in serotonin 2A receptor (5-HT(2A) R) binding with age could be replicated and whether high resolution research tomography (HRRT) for positron emission tomography could compensate for partial volume effects in the presence of age-related brain atrophy, which has been a traditional concern for radioligand PET studies in the elderly. METHODS: We derived 5-HT(2A) R nondisplaceable binding potentials (BP(ND) ) in frontal, temporal, anterior-cingulate, insula, caudate and putamen volumes of interest (VOIs) for 28 healthy subjects (mean ± SD age = 43.9 ± 17.0 years, range: 19-78 years) using HRRT. Partial volume correction (PVC) was performed in the VOI analysis. RESULTS: The 5-HT(2A) R BP(ND) s decreased with age, a relationship best described by an exponential-decay regression. The BP(ND) s were found to be consistent before and after PVC, with an intra-class correlation coefficient of 0.84 and 95% confidence interval = 0.78-0.88. CONCLUSIONS: These new findings update current knowledge, in that the aging process is not always uniform across the life span and suggest that PVC may not be necessary with HRRT in healthy subjects.
OBJECTIVE: We explored whether prior findings of reduction in serotonin 2A receptor (5-HT(2A) R) binding with age could be replicated and whether high resolution research tomography (HRRT) for positron emission tomography could compensate for partial volume effects in the presence of age-related brain atrophy, which has been a traditional concern for radioligand PET studies in the elderly. METHODS: We derived 5-HT(2A) R nondisplaceable binding potentials (BP(ND) ) in frontal, temporal, anterior-cingulate, insula, caudate and putamen volumes of interest (VOIs) for 28 healthy subjects (mean ± SD age = 43.9 ± 17.0 years, range: 19-78 years) using HRRT. Partial volume correction (PVC) was performed in the VOI analysis. RESULTS: The 5-HT(2A) R BP(ND) s decreased with age, a relationship best described by an exponential-decay regression. The BP(ND) s were found to be consistent before and after PVC, with an intra-class correlation coefficient of 0.84 and 95% confidence interval = 0.78-0.88. CONCLUSIONS: These new findings update current knowledge, in that the aging process is not always uniform across the life span and suggest that PVC may not be necessary with HRRT in healthy subjects.
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Authors: Jonathan M DuBois; Olivier G Rousset; Jared Rowley; Manuel Porras-Betancourt; Andrew J Reader; Aurelie Labbe; Gassan Massarweh; Jean-Paul Soucy; Pedro Rosa-Neto; Eliane Kobayashi Journal: Eur J Nucl Med Mol Imaging Date: 2015-08-21 Impact factor: 9.236
Authors: Fernando Caravaggio; Jun Ku Chung; Eric Plitman; Isabelle Boileau; Philip Gerretsen; Julia Kim; Yusuke Iwata; Raihaan Patel; M Mallar Chakravarty; Gary Remington; Ariel Graff-Guerrero Journal: Hum Brain Mapp Date: 2017-07-28 Impact factor: 5.038
Authors: Douglas N Greve; Claus Svarer; Patrick M Fisher; Ling Feng; Adam E Hansen; William Baare; Bruce Rosen; Bruce Fischl; Gitte M Knudsen Journal: Neuroimage Date: 2013-12-19 Impact factor: 6.556
Authors: Shinichiro Nakajima; Fernando Caravaggio; Isabelle Boileau; Jun K Chung; Eric Plitman; Philip Gerretsen; Alan A Wilson; Sylvain Houle; David C Mamo; Ariel Graff-Guerrero Journal: J Cereb Blood Flow Metab Date: 2015-06-10 Impact factor: 6.200
Authors: David Matuskey; Brian Pittman; Beata Planeta-Wilson; Espen Walderhaug; Shannan Henry; Jean-Dominique Gallezot; Nabeel Nabulsi; Yu-Shin Ding; Zubin Bhagwagar; Robert Malison; Richard E Carson; Alexander Neumeister Journal: J Nucl Med Date: 2012-07-31 Impact factor: 10.057