| Literature DB >> 21349711 |
Nigel S Watson1, Carl Adams, David Belton, David Brown, Cynthia L Burns-Kurtis, Laiq Chaudry, Chuen Chan, Máire A Convery, David E Davies, Anne M Exall, John D Harling, Stephanie Irvine, Wendy R Irving, Savvas Kleanthous, Iain M McLay, Anthony J Pateman, Angela N Patikis, Theresa J Roethke, Stefan Senger, Gary J Stelman, John R Toomey, Robert I West, Caroline Whittaker, Ping Zhou, Robert J Young.
Abstract
The discovery and evaluation of potent and long-acting oral sulfonamidopyrrolidin-2-one factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs are described. Unexpected selectivity issues versus tissue plasminogen activator in the former series were addressed in the later, delivering a robust candidate for progression towards clinical studies.Entities:
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Year: 2011 PMID： 21349711 DOI： 10.1016/j.bmcl.2011.01.129
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823