Literature DB >> 21349425

From the loading dock to the boardroom: a new job for Akt kinase.

Sonia Feau1, Stephen P Schoenberger.   

Abstract

A new report in Immunity shows that, rather than driving the metabolic changes required for proliferation, Akt controls the gene expression programs that determine whether activated CD8+ T cells differentiate into memory or effector cells.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 21349425      PMCID： PMC3388533          DOI： 10.1016/j.immuni.2011.02.013

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  9 in total

1.  Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes.

Authors:  N Manjunath; P Shankar; J Wan; W Weninger; M A Crowley; K Hieshima; T A Springer; X Fan; H Shen; J Lieberman; U H von Andrian
Journal:  J Clin Invest       Date:  2001-09       Impact factor: 14.808

2.  A single naive CD8+ T cell precursor can develop into diverse effector and memory subsets.

Authors:  Christian Stemberger; Katharina M Huster; Martina Koffler; Florian Anderl; Matthias Schiemann; Hermann Wagner; Dirk H Busch
Journal:  Immunity       Date:  2007-12       Impact factor: 31.745

Review 3.  A brief introduction to FOXOlogy.

Authors:  B M Th Burgering
Journal:  Oncogene       Date:  2008-04-07       Impact factor: 9.867

4.  Stable activation of phosphatidylinositol 3-kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control.

Authors:  Stéphanie Fabre; Valérie Lang; Julie Harriague; Aude Jobart; Terry G Unterman; Alain Trautmann; Georges Bismuth
Journal:  J Immunol       Date:  2005-04-01       Impact factor: 5.422

Review 5.  Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration.

Authors:  David Finlay; Doreen Cantrell
Journal:  Ann N Y Acad Sci       Date:  2010-01       Impact factor: 5.691

Review 6.  The cunning little vixen: Foxo and the cycle of life and death.

Authors:  Stephen M Hedrick
Journal:  Nat Immunol       Date:  2009-08-23       Impact factor: 25.606

7.  Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.

Authors:  Yann M Kerdiles; Daniel R Beisner; Roberto Tinoco; Anne S Dejean; Diego H Castrillon; Ronald A DePinho; Stephen M Hedrick
Journal:  Nat Immunol       Date:  2009-01-11       Impact factor: 25.606

Review 8.  Critical roles of the PI3K/Akt signaling pathway in T cell development.

Authors:  Marisa M Juntilla; Gary A Koretzky
Journal:  Immunol Lett       Date:  2008-01-10       Impact factor: 3.685

9.  Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.

Authors:  Andrew N Macintyre; David Finlay; Gavin Preston; Linda V Sinclair; Caryll M Waugh; Peter Tamas; Carmen Feijoo; Klaus Okkenhaug; Doreen A Cantrell
Journal:  Immunity       Date:  2011-02-03       Impact factor: 31.745
  9 in total
  2 in total

1.  Signal integration by Akt regulates CD8 T cell effector and memory differentiation.

Authors:  Eui Ho Kim; Jeremy A Sullivan; Erin H Plisch; Melba Marie Tejera; Anna Jatzek; Kwan Yong Choi; M Suresh
Journal:  J Immunol       Date:  2012-03-30       Impact factor: 5.422

2.  The PDL1-inducible GTPase Arl4d controls T effector function by limiting IL-2 production.

Authors:  Felix Tolksdorf; Julita Mikulec; Bernd Geers; Jessica Endig; Paulina Sprezyna; Lukas C Heukamp; Percy A Knolle; Waldemar Kolanus; Linda Diehl
Journal:  Sci Rep       Date:  2018-10-31       Impact factor: 4.379
  2 in total

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