Literature DB >> 21349423

RAG-2 unleashed: lymphocytes beware.

Sebastian D Fugmann1.   

Abstract

The programmed degradation of the RAG-2 enzyme upon entry to S phase restricts V(D)J recombination to the G0-G1 phase of the cell cycle. In this issue of Immunity, Zhang et al. (2011) show that this is critical to prevent lymphoma formation.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 21349423      PMCID： PMC3059897          DOI： 10.1016/j.immuni.2011.02.007

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  8 in total

Review 1.  Temporal and spatial regulatory functions of the V(D)J recombinase.

Authors:  Stephen Desiderio
Journal:  Semin Immunol       Date:  2010-10-30       Impact factor: 11.130

2.  Rag mutations reveal robust alternative end joining.

Authors:  Barbara Corneo; Rebecca L Wendland; Ludovic Deriano; Xiaoping Cui; Isaac A Klein; Serre-Yu Wong; Suzzette Arnal; Abigail J Holub; Geoffrey R Weller; Bette A Pancake; Sundeep Shah; Vicky L Brandt; Katheryn Meek; David B Roth
Journal:  Nature       Date:  2007-09-27       Impact factor: 49.962

Review 3.  Regulation of DNA repair throughout the cell cycle.

Authors:  Dana Branzei; Marco Foiani
Journal:  Nat Rev Mol Cell Biol       Date:  2008-02-20       Impact factor: 94.444

4.  Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis.

Authors:  Li Zhang; Taylor L Reynolds; Xiaochuan Shan; Stephen Desiderio
Journal:  Immunity       Date:  2011-02-25       Impact factor: 31.745

Review 5.  Origin and evolution of the adaptive immune system: genetic events and selective pressures.

Authors:  Martin F Flajnik; Masanori Kasahara
Journal:  Nat Rev Genet       Date:  2009-12-08       Impact factor: 53.242

6.  Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development.

Authors:  Y Gao; D O Ferguson; W Xie; J P Manis; J Sekiguchi; K M Frank; J Chaudhuri; J Horner; R A DePinho; F W Alt
Journal:  Nature       Date:  2000-04-20       Impact factor: 49.962

7.  A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex.

Authors:  Sathees C Raghavan; Patrick C Swanson; Xiantuo Wu; Chih-Lin Hsieh; Michael R Lieber
Journal:  Nature       Date:  2004-03-04       Impact factor: 49.962

Review 8.  Mechanism and regulation of class switch recombination.

Authors:  Janet Stavnezer; Jeroen E J Guikema; Carol E Schrader
Journal:  Annu Rev Immunol       Date:  2008       Impact factor: 28.527
  8 in total
  1 in total

1.  AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].

Authors:  Sanjay Ranjit; Lyne Khair; Erin K Linehan; Anna J Ucher; Mrinmay Chakrabarti; Carol E Schrader; Janet Stavnezer
Journal:  J Immunol       Date:  2011-07-29       Impact factor: 5.422
  1 in total

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