AIMS: To investigate TTF-1-negative pulmonary adenocarcinoma, focusing upon mucin production and the expression of hepatocyte nuclear factor-4α (HNF4α). MATERIALS AND METHODS: Two hundred and sixty-two cases of pulmonary adenocarcinoma were examined histologically and immunohistochemically; TTF-1 was expressed in 222 cases (84.7%), and 40 cases (15.3%) were negative. Among TTF-1-negative cases there were 31 mucinous-type tumours, and HNF4α, MUC5AC and MUC2 were expressed in 34 cases (85%), 29 cases (72.5%) and four cases (10%), respectively. In contrast, their expression was rare in TTF-1-positive tumours. A statistically inverse correlation was confirmed between the expression of TTF-1 and that of HNF4α and MUC5AC. CONCLUSION: Most TTF-1-negative pulmonary adenocarcinomas are mucinous lesions with the predominant expression of HNF4α and MUC5AC.
AIMS: To investigate TTF-1-negative pulmonary adenocarcinoma, focusing upon mucin production and the expression of hepatocyte nuclear factor-4α (HNF4α). MATERIALS AND METHODS: Two hundred and sixty-two cases of pulmonary adenocarcinoma were examined histologically and immunohistochemically; TTF-1 was expressed in 222 cases (84.7%), and 40 cases (15.3%) were negative. Among TTF-1-negative cases there were 31 mucinous-type tumours, and HNF4α, MUC5AC and MUC2 were expressed in 34 cases (85%), 29 cases (72.5%) and four cases (10%), respectively. In contrast, their expression was rare in TTF-1-positive tumours. A statistically inverse correlation was confirmed between the expression of TTF-1 and that of HNF4α and MUC5AC. CONCLUSION: Most TTF-1-negative pulmonary adenocarcinomas are mucinous lesions with the predominant expression of HNF4α and MUC5AC.
Authors: Laurence Josset; Jessica A Belser; Mary J Pantin-Jackwood; Jean H Chang; Stewart T Chang; Sarah E Belisle; Terrence M Tumpey; Michael G Katze Journal: J Virol Date: 2012-04-24 Impact factor: 5.103
Authors: Herwig P Moll; Klemens Pranz; Monica Musteanu; Beatrice Grabner; Natascha Hruschka; Julian Mohrherr; Petra Aigner; Patricia Stiedl; Luka Brcic; Viktoria Laszlo; Daniel Schramek; Richard Moriggl; Robert Eferl; Judit Moldvay; Katalin Dezso; Pedro P Lopez-Casas; Dagmar Stoiber; Manuel Hidalgo; Josef Penninger; Maria Sibilia; Balázs Győrffy; Mariano Barbacid; Balázs Dome; Helmut Popper; Emilio Casanova Journal: Sci Transl Med Date: 2018-06-20 Impact factor: 17.956
Authors: Eric L Snyder; Hideo Watanabe; Margaret Magendantz; Sebastian Hoersch; Tiffany A Chen; Diana G Wang; Denise Crowley; Charles A Whittaker; Matthew Meyerson; Shioko Kimura; Tyler Jacks Journal: Mol Cell Date: 2013-03-21 Impact factor: 17.970
Authors: Julia E Rager; Kim Lichtveld; Seth Ebersviller; Lisa Smeester; Ilona Jaspers; Kenneth G Sexton; Rebecca C Fry Journal: Environ Health Perspect Date: 2011-07-14 Impact factor: 9.031