| Literature DB >> 21348447 |
Rhys Finlayson1, A Norrie Pearce, Michael J Page, Marcel Kaiser, Marie-Lise Bourguet-Kondracki, Jacquie L Harper, Victoria L Webb, Brent R Copp.
Abstract
Two new indole spermidine alkaloids, didemnidines A (1) and B (2), have been isolated from the New Zealand ascidian Didemnum sp. The structures of the metabolites, determined by analysis of 2D NMR spectra and confirmed via synthesis, embody an indole-3-glyoxylamide moiety linked to the N(1) position of spermidine, the latter motif being particularly rare among marine natural products. Didemnidine B and a synthetic precursor exhibited mild in vitro growth inhibition of Plasmodium falciparum with IC(50)'s of 15 and 8.4 μM, respectively.Entities:
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Year: 2011 PMID： 21348447 DOI： 10.1021/np1008619
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050