Literature DB >> 21347701

Identification and characterization of RNF2 response elements in human kidney cells.

Dongwon Choi1, Seongman Kang.   

Abstract

RING finger protein 2 (RNF2) contains a conserved N-terminal RING finger domain and functions as an E3 ligase. As a member of the Polycomb group family of proteins, RNF2 also represses a number of genes involved in development, differentiation, malignant transformation and cell cycle. Herein, using chromatin immunoprecipitation cloning, 33 RNF2-responding loci were identified in the genome of HEK293 human kidney cells. Luciferase reporter assays showed that among them, 26 and 2 loci acted as a repressor and an activator, respectively. RNA interference revealed that the identified RNF2-responding sequences regulated the transcriptional activity of nearby promoters. This study may contribute to elucidating the mechanism underlying RNF2-mediated transcriptional regulation.

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Year:  2011        PMID： 21347701      PMCID： PMC3932698          DOI： 10.1007/s10059-011-0033-7

Source DB:  PubMed          Journal:  Mol Cells        ISSN： 1016-8478            Impact factor:   5.034


  24 in total

Review 1.  Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins.

Authors:  Leonie Ringrose; Renato Paro
Journal:  Annu Rev Genet       Date:  2004       Impact factor: 16.830

2.  Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation.

Authors:  Mariana de Napoles; Jacqueline E Mermoud; Rika Wakao; Y Amy Tang; Mitusuhiro Endoh; Ruth Appanah; Tatyana B Nesterova; Jose Silva; Arie P Otte; Miguel Vidal; Haruhiko Koseki; Neil Brockdorff
Journal:  Dev Cell       Date:  2004-11       Impact factor: 12.270

3.  Polycomb complexes repress developmental regulators in murine embryonic stem cells.

Authors:  Laurie A Boyer; Kathrin Plath; Julia Zeitlinger; Tobias Brambrink; Lea A Medeiros; Tong Ihn Lee; Stuart S Levine; Marius Wernig; Adriana Tajonar; Mridula K Ray; George W Bell; Arie P Otte; Miguel Vidal; David K Gifford; Richard A Young; Rudolf Jaenisch
Journal:  Nature       Date:  2006-04-19       Impact factor: 49.962

4.  Identification and characterization of polyhomeotic PREs and TREs.

Authors:  Sébastien Bloyer; Giacomo Cavalli; Hugh W Brock; Jean-Maurice Dura
Journal:  Dev Biol       Date:  2003-09-15       Impact factor: 3.582

5.  Choice of the adequate detection time for the accurate evaluation of the efficiency of siRNA-induced gene silencing.

Authors:  Inho Choi; Bum-Rae Cho; Donghee Kim; Shuji Miyagawa; Tomoko Kubo; Jae Young Kim; Chung-Gyu Park; Woo Suk Hwang; Jung Sang Lee; Curie Ahn
Journal:  J Biotechnol       Date:  2005-08-10       Impact factor: 3.307

6.  E3 ubiquitin ligase RNF2 interacts with the S6' proteasomal ATPase subunit and increases the ATP hydrolysis activity of S6'.

Authors:  Sun-Joo Lee; Dongwon Choi; Hyangshuk Rhim; Seongman Kang
Journal:  Biochem J       Date:  2005-07-15       Impact factor: 3.857

7.  Chromatin-remodeling factor INI1/hSNF5/BAF47 is involved in activation of the colony stimulating factor 1 promoter.

Authors:  Xuefang Pan; Zhaoxia Song; Lei Zhai; Xiaoyun Li; Xianlu Zeng
Journal:  Mol Cells       Date:  2005-10-31       Impact factor: 5.034

8.  Drosophila DSP1 and rat HMGB1 have equivalent DNA binding properties and share a similar secondary fold.

Authors:  Carsten Janke; Davy Martin; Marie-Josèphe Giraud-Panis; Martine Decoville; Daniel Locker
Journal:  J Biochem       Date:  2003-04       Impact factor: 3.387

9.  The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1.

Authors:  J L Brown; D Mucci; M Whiteley; M L Dirksen; J A Kassis
Journal:  Mol Cell       Date:  1998-06       Impact factor: 17.970

10.  Variability in the expression of polycomb proteins in different normal and tumoral tissues. A pilot study using tissue microarrays.

Authors:  Margarita Sánchez-Beato; Esther Sánchez; Joaquín González-Carreró; Manuel Morente; Ana Díez; Lydia Sánchez-Verde; María Carmen Martín; Juan C Cigudosa; Miguel Vidal; Miguel A Piris
Journal:  Mod Pathol       Date:  2006-05       Impact factor: 7.842
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  4 in total

1.  Enhanced intratumoral expression of RNF2 is a favorable prognostic factor for patients with cutaneous melanoma?

Authors:  Łukasz Kuźbicki; Dariusz Lange; Agata Stanek-Widera; Agnieszka Glińska; Barbara W Chwirot
Journal:  Oncotarget       Date:  2018-04-03

2.  RNF2 Mediates Hepatic Stellate Cells Activation by Regulating ERK/p38 Signaling Pathway in LX-2 Cells.

Authors:  Qi Yan; Linxin Pan; Shunli Qi; Fang Liu; Zhen Wang; Cheng Qian; Lijian Chen; Jian Du
Journal:  Front Cell Dev Biol       Date:  2021-03-18

3.  MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells.

Authors:  Anne-Marie M Gannon; Aisling Frizzell; Evan Healy; Robert S Lahue
Journal:  Nucleic Acids Res       Date:  2012-08-31       Impact factor: 16.971

4.  Changing expression profiles of long non-coding RNAs, mRNAs and circular RNAs in ethylene glycol-induced kidney calculi rats.

Authors:  Yanan Cao; Xiaowei Gao; Yue Yang; Zhi Ye; E Wang; Zhitao Dong
Journal:  BMC Genomics       Date:  2018-09-10       Impact factor: 3.969
  4 in total

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