Literature DB >> 21344846

A new cytotoxic metabolite from a deep sea derived fungus, Phialocephala sp.

Li Chen1, De-hai Li, Sheng-xin Cai, Feng-ping Wang, Xiang Xiao, Qian-qun Gu.   

Abstract

A new sesquiterpene hydroquinone (1) was isolated from a deep sea sediment derived fungus, Phialocephala sp.. Its structure and stereochemistry were established on the basis of spectroscopic data and optical rotation. This compound was tested for cytotoxicity against P388 (murine leukemia cell) and K562 (human leukemia cell) cell lines, and displayed strong cytotoxic effects with IC50 value of 0.16 and 0.05 micromol x L(-1), separately.

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Year:  2010        PMID： 21344846

Source DB:  PubMed          Journal:  Yao Xue Xue Bao        ISSN： 0513-4870


  3 in total

1.  Purpurogemutantin and purpurogemutantidin, new drimenyl cyclohexenone derivatives produced by a mutant obtained by diethyl sulfate mutagenesis of a marine-derived Penicillium purpurogenum G59.

Authors:  Shi-Ming Fang; Cheng-Bin Cui; Chang-Wei Li; Chang-Jing Wu; Zhi-Jun Zhang; Li Li; Xiao-Jun Huang; Wen-Cai Ye
Journal:  Mar Drugs       Date:  2012-06-04       Impact factor: 6.085

2.  Two new amides from a halotolerant fungus, Myrothecium sp. GS-17.

Authors:  Tao Liu; Songya Zhang; Jing Zhu; Huaqi Pan; Jiao Bai; Zhanlin Li; Liping Guan; Guyue Liu; Chunmao Yuan; Xin Wu; Huiming Hua
Journal:  J Antibiot (Tokyo)       Date:  2014-10-01       Impact factor: 2.649

Review 3.  A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi.

Authors:  Yan-Ting Wang; Ya-Rong Xue; Chang-Hong Liu
Journal:  Mar Drugs       Date:  2015-07-23       Impact factor: 5.118
  3 in total

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