Literature DB >> 21344497

Effect of low-magnitude, high-frequency vibration on osteogenic differentiation of rat mesenchymal stromal cells.

Esther Lau1, W David Lee, Jason Li, Andrew Xiao, John E Davies, Qianhong Wu, Liyun Wang, Lidan You.   

Abstract

Whole body vibration (WBV), consisting of a low-magnitude, high-frequency (LMHF) signal, is anabolic to bone in vivo and may act through alteration of the lineage commitment of mesenchymal stromal cells (MSC). We investigated the effect of LMHF vibration on rat bone marrow-derived MSCs (rMSCs) in an in vitro system. We subjected rMSCs to repeated (six) bouts of 1-h vibration at 0.3g and 60 Hz in the presence of osteogenic (OS) induction medium. The OS differentiation of rMSCs under the loaded and non-loaded conditions was assessed by examining cell proliferation, alkaline phosphatase (ALP) activity, mRNA expression of various osteoblast-associated markers [ALP, Runx2, osterix (Osx), collagen type I alpha 1 (COL1A1), bone sialoprotein (BSP), osteopontin (OPN), and osteocalcin (OCN)], and matrix mineralization. LMHF vibration did not enhance the OS differentiation of rMSCs. Surprisingly, the mRNA level of Osx, a transcription factor necessary for osteoblast formation, was decreased, and matrix mineralization was inhibited. Our findings suggest that LMHF vibration may exert its anabolic effects in vivo via mechanosensing of a cell type different from MSCs.
Copyright © 2011 Orthopaedic Research Society.

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Year:  2011        PMID： 21344497      PMCID： PMC3119487          DOI： 10.1002/jor.21334

Source DB:  PubMed          Journal:  J Orthop Res        ISSN： 0736-0266            Impact factor:   3.494


  36 in total

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Journal:  Exp Cell Res       Date:  2004-04-01       Impact factor: 3.905

5.  Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation.

Authors:  Ying Jun Li; Nikhil N Batra; Lidan You; Stephen C Meier; Ian A Coe; Clare E Yellowley; Christopher R Jacobs
Journal:  J Orthop Res       Date:  2004-11       Impact factor: 3.494

6.  Effect of low-magnitude, high-frequency vibration on osteocytes in the regulation of osteoclasts.

Authors:  Esther Lau; Saja Al-Dujaili; Axel Guenther; Dawei Liu; Liyun Wang; Lidan You
Journal:  Bone       Date:  2010-03-06       Impact factor: 4.398

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  22 in total

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Authors:  Rishikesh N Kulkarni; Philip A Voglewede; Dawei Liu
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2.  Mesenchymal stem cell responses to mechanical stimuli.

Authors:  Robin M Delaine-Smith; Gwendolen C Reilly
Journal:  Muscles Ligaments Tendons J       Date:  2012-10-16

Review 3.  Vibration stimuli and the differentiation of musculoskeletal progenitor cells: Review of results in vitro and in vivo.

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Journal:  World J Stem Cells       Date:  2015-04-26       Impact factor: 5.326

4.  Biomechanical Screening of Cell Therapies for Vocal Fold Scar.

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5.  Cell Mechanosensitivity to Extremely Low-Magnitude Signals Is Enabled by a LINCed Nucleus.

Authors:  Gunes Uzer; William R Thompson; Buer Sen; Zhihui Xie; Sherwin S Yen; Sean Miller; Guniz Bas; Maya Styner; Clinton T Rubin; Stefan Judex; Keith Burridge; Janet Rubin
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6.  Treadmill training regulates β-catenin signaling through phosphorylation of GSK-3β in lumbar vertebrae of ovariectomized rats.

Authors:  Shumin Bu; Yu Chen; Shouhui Wang; Fan Zhang; Gang Ji
Journal:  Eur J Appl Physiol       Date:  2012-01-18       Impact factor: 3.078

7.  Separating Fluid Shear Stress from Acceleration during Vibrations in Vitro: Identification of Mechanical Signals Modulating the Cellular Response.

Authors:  Gunes Uzer; Sarah L Manske; M Ete Chan; Fu-Pen Chiang; Clinton T Rubin; Mary D Frame; Stefan Judex
Journal:  Cell Mol Bioeng       Date:  2012-05-09       Impact factor: 2.321

8.  Magnetically actuated tissue engineered scaffold: insights into mechanism of physical stimulation.

Authors:  Yulia Sapir-Lekhovitser; Menahem Y Rotenberg; Juergen Jopp; Gary Friedman; Boris Polyak; Smadar Cohen
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9.  Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model.

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Journal:  Blood       Date:  2014-09-09       Impact factor: 22.113

10.  Low-magnitude high-frequency vibration inhibits RANKL-induced osteoclast differentiation of RAW264.7 cells.

Authors:  Song-Hui Wu; Zhao-Ming Zhong; Jian-Ting Chen
Journal:  Int J Med Sci       Date:  2012-10-26       Impact factor: 3.738
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