Literature DB >> 21343747

Severe hypoglycemic seizures in a child receiving 6-mercaptopurine.

Mohamad K El-Bitar1, Samar A Muwakkit, Omar Dabbagh.   

Abstract

A 4-year-old boy with acute lymphoblastic leukemia who was receiving 6-mercaptopurine during the maintenance chemotherapy experienced prolonged generalized tonic nocturnal seizures because of severe hypoglycemia after his evening dose by a 12-hour period of fasting. Investigations ruled out all causes of these seizures other than the 6-mercaptopurine-induced severe hypoglycemia.

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Year:  2011        PMID： 21343747     DOI： 10.1097/MPH.0b013e3182025507

Source DB:  PubMed          Journal:  J Pediatr Hematol Oncol        ISSN： 1077-4114            Impact factor:   1.289


  3 in total

1.  6-Mercaptopurine augments glucose transport activity in skeletal muscle cells in part via a mechanism dependent upon orphan nuclear receptor NR4A3.

Authors:  Qinglan Liu; Xiaolin Zhu; Lusheng Xu; Yuchang Fu; W Timothy Garvey
Journal:  Am J Physiol Endocrinol Metab       Date:  2013-09-10       Impact factor: 4.310

2.  Incidence and risk factors for hypoglycemia during maintenance chemotherapy in pediatric acute lymphoblastic leukemia.

Authors:  Elizabeth Rosenfeld; Kelly D Getz; Tamara P Miller; Alix E Seif; Brian T Fisher; Evanette Burrows; Mark Jason Ramos; Diva D De León; Richard Aplenc; Knashawn H Morales; James P Guevara
Journal:  Pediatr Blood Cancer       Date:  2021-11-22       Impact factor: 3.838

Review 3.  Mercaptopurine/Methotrexate maintenance therapy of childhood acute lymphoblastic leukemia: clinical facts and fiction.

Authors:  Kjeld Schmiegelow; Stine N Nielsen; Thomas L Frandsen; Jacob Nersting
Journal:  J Pediatr Hematol Oncol       Date:  2014-10       Impact factor: 1.289
  3 in total

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