Literature DB >> 21343451

Outbreak of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in France.

Gaelle Cuzon1, Jocelyne Ouanich, Remy Gondret, Thierry Naas, Patrice Nordmann.   

Abstract

Seventeen Klebsiella pneumoniae isolates producing the OXA-48 carbapenemase, obtained from 10 patients hospitalized from April to June 2010, mostly in the medical intensive care unit of the Villeneuve-Saint-Georges Hospital in a suburb of Paris, France, were analyzed. Seven patients were infected, of whom five were treated at least with a carbapenem, and five patients died. Molecular analysis showed that the isolates belonged to a single clone that harbored a 70-kb plasmid carrying the blaOXA-48 gene and coproduced CTX-M-15 and TEM-1 β-lactamases. This is the first reported outbreak of OXA-48-producing K. pneumoniae isolates in France.

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Year:  2011        PMID： 21343451      PMCID： PMC3088266          DOI： 10.1128/AAC.01452-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

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Review 2.  Carbapenemases: the versatile beta-lactamases.

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4.  Characterization of a large outbreak by CTX-M-1-producing Klebsiella pneumoniae and mechanisms leading to in vivo carbapenem resistance development.

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Journal:  J Clin Microbiol       Date:  2006-08       Impact factor: 5.948

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8.  Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae isolates from Turkey with OXA-48-like carbapenemases and outer membrane protein loss.

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  76 in total

1.  Genetic features of the widespread plasmid coding for the carbapenemase OXA-48.

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4.  Clinical Performance of Check-Direct CPE, a Multiplex PCR for Direct Detection of bla(KPC), bla(NDM) and/or bla(VIM), and bla(OXA)-48 from Perirectal Swabs.

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5.  Derepressed transfer properties leading to the efficient spread of the plasmid encoding carbapenemase OXA-48.

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6.  Occurrence of the carbapenem-hydrolyzing beta-lactamase gene blaOXA-48 in the environment in Morocco.

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7.  Screening rectal swabs for carbapenemase genes.

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8.  Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.

Authors:  E Miró; J Agüero; M N Larrosa; A Fernández; M C Conejo; G Bou; J J González-López; N Lara; L Martínez-Martínez; A Oliver; B Aracil; J Oteo; A Pascual; J Rodríguez-Baño; L Zamorano; F Navarro
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2012-09-07       Impact factor: 3.267

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Journal:  J Clin Microbiol       Date:  2013-06-26       Impact factor: 5.948

10.  Class D β-lactamases: are they all carbapenemases?

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Journal:  Antimicrob Agents Chemother       Date:  2014-01-27       Impact factor: 5.191
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