Literature DB >> 21342787

5-HT(4) receptors, a place in the sun: act two.

Joël Bockaert1, Sylvie Claeysen, Valérie Compan, Aline Dumuis.   

Abstract

5-HT(4) receptors control brain physiological functions such as learning and memory, feeding and mood behaviour as well as gastro-intestinal transit. 5-HT(4) receptors are one of the 5-HT receptors for which the available drugs and signalling knowledge are the most advanced. Several therapeutic 5-HT(4) receptor drugs have been commercialized. Therefore, the hope that 5-HT(4) receptors could also be the target for brain diseases is reasonable. Several major devastating illnesses could benefit from 5-HT(4) receptors-directed therapy such as Alzheimer's disease, feeding-associated diseases such as anorexia and major depressive disorders.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21342787     DOI： 10.1016/j.coph.2011.01.012

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  19 in total

1.  Post-translational modifications of the serotonin type 4 receptor heterologously expressed in mouse rod cells.

Authors:  David Salom; Benlian Wang; Zhiqian Dong; Wenyu Sun; Pius Padayatti; Steven Jordan; John A Salon; Krzysztof Palczewski
Journal:  Biochemistry       Date:  2011-12-20       Impact factor: 3.162

2.  Serotonin signaling by maternal neurons upon stress ensures progeny survival.

Authors:  Srijit Das; Felicia K Ooi; Johnny Cruz Corchado; Leah C Fuller; Joshua A Weiner; Veena Prahlad
Journal:  Elife       Date:  2020-04-23       Impact factor: 8.140

3.  Influence of phosphodiesterases and cGMP on cAMP generation and on phosphorylation of phospholamban and troponin I by 5-HT4 receptor activation in porcine left atrium.

Authors:  Sabine Weninger; Joris H De Maeyer; Romain A Lefebvre
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-04-03       Impact factor: 3.000

4.  The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.

Authors:  Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; Michael Spedding; John A Peters; Anthony J Harmar
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

5.  Hippocampal 5-HT Input Regulates Memory Formation and Schaffer Collateral Excitation.

Authors:  Catia M Teixeira; Zev B Rosen; Deepika Suri; Qian Sun; Marc Hersh; Derya Sargin; Iva Dincheva; Ashlea A Morgan; Stephen Spivack; Anne C Krok; Tessa Hirschfeld-Stoler; Evelyn K Lambe; Steven A Siegelbaum; Mark S Ansorge
Journal:  Neuron       Date:  2018-05-10       Impact factor: 17.173

6.  5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10.

Authors:  Maud Cochet; Romain Donneger; Elisabeth Cassier; Florence Gaven; Stefan F Lichtenthaler; Philippe Marin; Joël Bockaert; Aline Dumuis; Sylvie Claeysen
Journal:  ACS Chem Neurosci       Date:  2012-10-13       Impact factor: 4.418

Review 7.  Serotonin receptors and their role in the pathophysiology and therapy of irritable bowel syndrome.

Authors:  C Stasi; M Bellini; G Bassotti; C Blandizzi; S Milani
Journal:  Tech Coloproctol       Date:  2014-01-15       Impact factor: 3.781

8.  Evaluation in monkey of two candidate PET radioligands, [11 C]RX-1 and [18 F]RX-2, for imaging brain 5-HT4 receptors.

Authors:  Talakad G Lohith; Rong Xu; Tetsuya Tsujikawa; Cheryl L Morse; Kacey B Anderson; Robert L Gladding; Sami S Zoghbi; Masahiro Fujita; Robert B Innis; Victor W Pike
Journal:  Synapse       Date:  2014-08-11       Impact factor: 2.562

Review 9.  The use of animal models to decipher physiological and neurobiological alterations of anorexia nervosa patients.

Authors:  Mathieu Méquinion; Christophe Chauveau; Odile Viltart
Journal:  Front Endocrinol (Lausanne)       Date:  2015-05-19       Impact factor: 5.555

Review 10.  Serotonin, neural markers, and memory.

Authors:  Alfredo Meneses
Journal:  Front Pharmacol       Date:  2015-07-21       Impact factor: 5.810
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