J Hellström1, A Öwall, J Bergström, P V Sackey. 1. Institution of Molecular Medicine and Surgery, Section of Cardiothoracic Surgery and Anesthesiology, Karolinska Institutet, Stockholm, Sweden. jan.hellstrom@karolinska.se
Abstract
BACKGROUND: Studies of volatile anesthetic administration during coronary artery bypass grafting (CABG) report reduced serum levels of post-operative cardiac troponin-T (cTnT). Our primary objective was to evaluate whether short-term sedation with sevoflurane in the intensive care unit (ICU)--after CABG--could affect the release of cTnT, compared with propofol sedation. METHODS: Following isolated CABG with cardiopulmonary bypass, 100 patients were randomized to either sevoflurane via the Anesthetic Conserving Device (AnaConDa(®)) or propofol for ICU sedation. Study drugs were administered for 2 h during mechanical ventilation and thereafter until extubation criteria were met. The primary endpoint was cTnT 12 h post-operatively. Crude cTnT data were not normally distributed and therefore compared with the Mann-Whitney U-test. Because of the skewed pre-operative and post-operative cTnT data, we performed a post hoc analysis of the change in cTnT between pre-operative values and 12 h post-operatively. RESULTS: There was no statistically significant difference between groups in the primary endpoint cTnT values at 12 h post-operatively, cardiac events or the need for hemodynamic support. In the post hoc analysis, the cTnT increase from pre-operative values to 12 h post-operatively was less pronounced in the sevoflurane group (P=0.008). CONCLUSION: Post-operative short-term sevoflurane sedation following CABG, in comparison with propofol, did not affect the cTnT values at 12 h post-operatively and clinical outcome was equal between groups. The result from the post hoc analysis, with less cTnT change over time, is nevertheless hypothesis-generating and warrants a larger study.
RCT Entities:
BACKGROUND: Studies of volatile anesthetic administration during coronary artery bypass grafting (CABG) report reduced serum levels of post-operative cardiac troponin-T (cTnT). Our primary objective was to evaluate whether short-term sedation with sevoflurane in the intensive care unit (ICU)--after CABG--could affect the release of cTnT, compared with propofol sedation. METHODS: Following isolated CABG with cardiopulmonary bypass, 100 patients were randomized to either sevoflurane via the Anesthetic Conserving Device (AnaConDa(®)) or propofol for ICU sedation. Study drugs were administered for 2 h during mechanical ventilation and thereafter until extubation criteria were met. The primary endpoint was cTnT 12 h post-operatively. Crude cTnT data were not normally distributed and therefore compared with the Mann-Whitney U-test. Because of the skewed pre-operative and post-operative cTnT data, we performed a post hoc analysis of the change in cTnT between pre-operative values and 12 h post-operatively. RESULTS: There was no statistically significant difference between groups in the primary endpoint cTnT values at 12 h post-operatively, cardiac events or the need for hemodynamic support. In the post hoc analysis, the cTnT increase from pre-operative values to 12 h post-operatively was less pronounced in the sevoflurane group (P=0.008). CONCLUSION: Post-operative short-term sevoflurane sedation following CABG, in comparison with propofol, did not affect the cTnT values at 12 h post-operatively and clinical outcome was equal between groups. The result from the post hoc analysis, with less cTnT change over time, is nevertheless hypothesis-generating and warrants a larger study.
Authors: John M Bonvini; Beatrice Beck-Schimmer; Sonja J Kuhn; Sereina M Graber; Thomas A Neff; Martin Schläpfer Journal: PLoS One Date: 2015-07-21 Impact factor: 3.240
Authors: Jose Luis Guerrero-Orriach; Juan Jose Escalona Belmonte; Alicia Ramirez Fernandez; Marta Ramirez Aliaga; Manuel Rubio Navarro; Jose Cruz Mañas Journal: Drug Des Devel Ther Date: 2017-03-16 Impact factor: 4.162
Authors: Marc P Steurer; Martina A Steurer; Werner Baulig; Tobias Piegeler; Martin Schläpfer; Donat R Spahn; Volkmar Falk; Pamela Dreessen; Oliver M Theusinger; Edith R Schmid; David Schwartz; Thomas A Neff; Beatrice Beck-Schimmer Journal: Crit Care Date: 2012-10-14 Impact factor: 9.097