Literature DB >> 21342108

Applications of molecular imaging in drug discovery and development process.

Byeong-Cheol Ahn1.   

Abstract

The process of drug discovery and development requires enormous resources and time, with increasing cost for new drug development. Molecular imaging techniques have tremendous potential for improving the efficiency of drug screening, assessing the pharmacokinetics of new drugs, and evaluating drug effects. Appropriate application of molecular imaging to drug discovery and development can markedly reduce costs and the time required for new drug development. This review focuses on the contributions of molecular imaging for drug discovery and development, particularly drug screening, pharmacokinetic, preclinical and clinical drug evaluation, and for personalized and lesionalized medicine.

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Year:  2011        PMID: 21342108     DOI: 10.2174/138920111795163904

Source DB:  PubMed          Journal:  Curr Pharm Biotechnol        ISSN: 1389-2010            Impact factor:   2.837


  13 in total

Review 1.  In vivo cell tracking with bioluminescence imaging.

Authors:  Jung Eun Kim; Senthilkumar Kalimuthu; Byeong-Cheol Ahn
Journal:  Nucl Med Mol Imaging       Date:  2014-11-26

2.  Nuclear Medicine in the Era of Precision Medicine.

Authors:  Byeong-Cheol Ahn
Journal:  Nucl Med Mol Imaging       Date:  2017-03-28

3.  Integration of Molecular, Cellular and Translational Researches in BioImpacts.

Authors:  Yadollah Omidi
Journal:  Bioimpacts       Date:  2011-06-09

4.  Use of Nuclear Medicine Technology for Clinical Molecular Imaging: a Message from the Associate Editor.

Authors:  Byeong-Cheol Ahn
Journal:  Nucl Med Mol Imaging       Date:  2016-04-11

Review 5.  The Valley of Death in anticancer drug development: a reassessment.

Authors:  David J Adams
Journal:  Trends Pharmacol Sci       Date:  2012-03-10       Impact factor: 14.819

6.  Macroscopic Fluorescence Lifetime Imaging for Monitoring of Drug-Target Engagement.

Authors:  Marien Ochoa; Alena Rudkouskaya; Jason T Smith; Xavier Intes; Margarida Barroso
Journal:  Methods Mol Biol       Date:  2022

7.  Impact of a multiple mice holder on quantitation of high-throughput MicroPET imaging with and without Ct attenuation correction.

Authors:  Frezghi Habte; Gang Ren; Timothy C Doyle; Hongguang Liu; Zhen Cheng; David S Paik
Journal:  Mol Imaging Biol       Date:  2013-10       Impact factor: 3.488

8.  Sodium iodide symporter for nuclear molecular imaging and gene therapy: from bedside to bench and back.

Authors:  Byeong-Cheol Ahn
Journal:  Theranostics       Date:  2012-04-11       Impact factor: 11.556

Review 9.  Personalized Medicine Based on Theranostic Radioiodine Molecular Imaging for Differentiated Thyroid Cancer.

Authors:  Byeong-Cheol Ahn
Journal:  Biomed Res Int       Date:  2016-04-28       Impact factor: 3.411

Review 10.  MicroSPECT and MicroPET Imaging of Small Animals for Drug Development.

Authors:  Beom-Su Jang
Journal:  Toxicol Res       Date:  2013-03
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