Literature DB >> 21341756

Synthetic studies on indolocarbazoles: total synthesis of staurosporine aglycon.

Ganesan Gobi Rajeshwaran1, Arasambattu K Mohanakrishnan.   

Abstract

A synthesis of staurosporine aglycon and its analogs was achieved in a 28-36% overall yield starting from 2-methylindole. The prominent key steps for the synthesis of the indolocarbazole alkaloids involved electrocyclization and nitrene insertion reactions.

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Year:  2011        PMID： 21341756     DOI： 10.1021/ol200094b

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Site-Selective Aerobic C-H Monoacylation of Carbazoles Using Palladium Catalysis.

Authors:  Subhadip Maiti; Tirtha Mandal; Barada Prasanna Dash; Jyotirmayee Dash
Journal:  J Org Chem       Date:  2020-12-31       Impact factor: 4.198

2.  Preparation of dibenzo[e,g]isoindol-1-ones via Scholl-type oxidative cyclization reactions.

Authors:  Amy A van Loon; Maeve K Holton; Catherine R Downey; Taryn M White; Carly E Rolph; Stephen R Bruening; Guanqun Li; Katherine M Delaney; Sarah J Pelkey; Erin T Pelkey
Journal:  J Org Chem       Date:  2014-08-25       Impact factor: 4.354

3.  The total synthesis of K-252c (staurosporinone) via a sequential C-H functionalisation strategy.

Authors:  J C Fox; R E Gilligan; A K Pitts; H R Bennett; M J Gaunt
Journal:  Chem Sci       Date:  2016-01-21       Impact factor: 9.825

4.  Precursor-Directed Generation of Indolocarbazoles with Topoisomerase IIα Inhibitory Activity.

Authors:  Cong Wang; Adeep Monger; Liping Wang; Peng Fu; Pawinee Piyachaturawat; Arthit Chairoungdua; Weiming Zhu
Journal:  Mar Drugs       Date:  2018-05-17       Impact factor: 5.118
  4 in total

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