Literature DB >> 21341712

N,N'-methyleno-didemnin A from the ascidian Trididemnum solidum. Complete NMR assignments and confirmation of the imidazolidinone ring by strategic analysis of 1J(CH).

Tadeusz F Molinski1, Jaeyoung Ko, Kirk A Reynolds, Sarah C Lievens, Katrina R Skarda.   

Abstract

The complete NMR assignments of N,N'-methyleno-didemnin A from Trididemnum solidum Van Name 1902 are reported along with a strategic analysis of (1)J(CH) coupling constants that confirm the presence of the imidazolidinone ring.

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Year:  2011        PMID： 21341712      PMCID： PMC3694603          DOI： 10.1021/np100846s

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  10 in total

1.  Phase II clinical and pharmacological study of didemnin B in patients with metastatic breast cancer.

Authors:  J A Benvenuto; R A Newman; G S Bignami; T J Raybould; M N Raber; L Esparza; R S Walters
Journal:  Invest New Drugs       Date:  1992-07       Impact factor: 3.850

Review 2.  Drug development from marine natural products.

Authors:  Tadeusz F Molinski; Doralyn S Dalisay; Sarah L Lievens; Jonel P Saludes
Journal:  Nat Rev Drug Discov       Date:  2008-12-19       Impact factor: 84.694

Review 3.  NMR of natural products at the 'nanomole-scale'.

Authors:  Tadeusz F Molinski
Journal:  Nat Prod Rep       Date:  2010-02-08       Impact factor: 13.423

4.  Phase I/II clinical trial of didemnin B in non-small-cell lung cancer: neuromuscular toxicity is dose-limiting.

Authors:  D M Shin; P Y Holoye; W K Murphy; A Forman; S C Papasozomenos; W K Hong; M Raber
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

5.  Phase II trail of didemnin B in previously treated non-Hodgkin's lymphoma: an Eastern Cooperative Oncology Group (ECOG) Study.

Authors:  O Kucuk; M L Young; T M Habermann; B C Wolf; J Jimeno; P A Cassileth
Journal:  Am J Clin Oncol       Date:  2000-06       Impact factor: 2.339

Review 6.  Didemnin B. The first marine compound entering clinical trials as an antineoplastic agent.

Authors:  H G Chun; B Davies; D Hoth; M Suffness; J Plowman; K Flora; C Grieshaber; B Leyland-Jones
Journal:  Invest New Drugs       Date:  1986       Impact factor: 3.850

Review 7.  Microscale methodology for structure elucidation of natural products.

Authors:  Tadeusz F Molinski
Journal:  Curr Opin Biotechnol       Date:  2010-09-27       Impact factor: 9.740

Review 8.  Natural products as probes of cell biology: 20 years of didemnin research.

Authors:  Matthew D Vera; Madeleine M Joullié
Journal:  Med Res Rev       Date:  2002-03       Impact factor: 12.944

Review 9.  Progress in the clinical development of new marine-derived anticancer compounds.

Authors:  Jose Jimeno; J A López-Martín; A Ruiz-Casado; M A Izquierdo; P J Scheuer; K Rinehart
Journal:  Anticancer Drugs       Date:  2004-04       Impact factor: 2.248

10.  NMR quantitation of natural products at the nanomole scale.

Authors:  Doralyn S Dalisay; Tadeusz F Molinski
Journal:  J Nat Prod       Date:  2009-04       Impact factor: 4.050
  10 in total
  1 in total

Review 1.  The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.

Authors:  James B McAlpine; Shao-Nong Chen; Andrei Kutateladze; John B MacMillan; Giovanni Appendino; Andersson Barison; Mehdi A Beniddir; Maique W Biavatti; Stefan Bluml; Asmaa Boufridi; Mark S Butler; Robert J Capon; Young H Choi; David Coppage; Phillip Crews; Michael T Crimmins; Marie Csete; Pradeep Dewapriya; Joseph M Egan; Mary J Garson; Grégory Genta-Jouve; William H Gerwick; Harald Gross; Mary Kay Harper; Precilia Hermanto; James M Hook; Luke Hunter; Damien Jeannerat; Nai-Yun Ji; Tyler A Johnson; David G I Kingston; Hiroyuki Koshino; Hsiau-Wei Lee; Guy Lewin; Jie Li; Roger G Linington; Miaomiao Liu; Kerry L McPhail; Tadeusz F Molinski; Bradley S Moore; Joo-Won Nam; Ram P Neupane; Matthias Niemitz; Jean-Marc Nuzillard; Nicholas H Oberlies; Fernanda M M Ocampos; Guohui Pan; Ronald J Quinn; D Sai Reddy; Jean-Hugues Renault; José Rivera-Chávez; Wolfgang Robien; Carla M Saunders; Thomas J Schmidt; Christoph Seger; Ben Shen; Christoph Steinbeck; Hermann Stuppner; Sonja Sturm; Orazio Taglialatela-Scafati; Dean J Tantillo; Robert Verpoorte; Bin-Gui Wang; Craig M Williams; Philip G Williams; Julien Wist; Jian-Min Yue; Chen Zhang; Zhengren Xu; Charlotte Simmler; David C Lankin; Jonathan Bisson; Guido F Pauli
Journal:  Nat Prod Rep       Date:  2018-07-13       Impact factor: 13.423
  1 in total

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