Literature DB >> 21340692

Recent progress in the study of the genetics of height.

Guillaume Lettre1.   

Abstract

Adult height is a classic polygenic trait of high narrow-sense heritability (h (2) = 0.8). In the late nineteenth to early twentieth century, variation in adult height was used as a model to set the foundation of the fields of statistics and quantitative genetics. More recently, with our increasing knowledge concerning the extent of genetic variation in the human genome, human geneticists have used genome-wide association studies to identify hundreds of loci robustly associated with adult height, providing new insights into human growth and development, and into the architecture of complex human traits. In this review, I highlight the progress made in the last 2 years in understanding how genetic variation controls height variation in humans, including non-Caucasian populations and children.

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Year:  2011        PMID: 21340692     DOI: 10.1007/s00439-011-0969-x

Source DB:  PubMed          Journal:  Hum Genet        ISSN: 0340-6717            Impact factor:   4.132


  45 in total

1.  Genetic regulation of growth from birth to 18 years of age: the Swedish young male twins study.

Authors:  Karri Silventoinen; Kirsi H Pietiläinen; Per Tynelius; Thorkild I A Sørensen; Jaakko Kaprio; Finn Rasmussen
Journal:  Am J Hum Biol       Date:  2008 May-Jun       Impact factor: 1.937

2.  Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

Authors:  Lucia A Hindorff; Praveen Sethupathy; Heather A Junkins; Erin M Ramos; Jayashri P Mehta; Francis S Collins; Teri A Manolio
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-27       Impact factor: 11.205

3.  Many sequence variants affecting diversity of adult human height.

Authors:  Daniel F Gudbjartsson; G Bragi Walters; Gudmar Thorleifsson; Hreinn Stefansson; Bjarni V Halldorsson; Pasha Zusmanovich; Patrick Sulem; Steinunn Thorlacius; Arnaldur Gylfason; Stacy Steinberg; Anna Helgadottir; Andres Ingason; Valgerdur Steinthorsdottir; Elinborg J Olafsdottir; Gudridur H Olafsdottir; Thorvaldur Jonsson; Knut Borch-Johnsen; Torben Hansen; Gitte Andersen; Torben Jorgensen; Oluf Pedersen; Katja K Aben; J Alfred Witjes; Dorine W Swinkels; Martin den Heijer; Barbara Franke; Andre L M Verbeek; Diane M Becker; Lisa R Yanek; Lewis C Becker; Laufey Tryggvadottir; Thorunn Rafnar; Jeffrey Gulcher; Lambertus A Kiemeney; Augustine Kong; Unnur Thorsteinsdottir; Kari Stefansson
Journal:  Nat Genet       Date:  2008-04-06       Impact factor: 38.330

4.  A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.

Authors:  Yukinori Okada; Yoichiro Kamatani; Atsushi Takahashi; Koichi Matsuda; Naoya Hosono; Hiroko Ohmiya; Yataro Daigo; Kazuhiko Yamamoto; Michiaki Kubo; Yusuke Nakamura; Naoyuki Kamatani
Journal:  Hum Mol Genet       Date:  2010-02-26       Impact factor: 6.150

5.  Common SNPs explain a large proportion of the heritability for human height.

Authors:  Jian Yang; Beben Benyamin; Brian P McEvoy; Scott Gordon; Anjali K Henders; Dale R Nyholt; Pamela A Madden; Andrew C Heath; Nicholas G Martin; Grant W Montgomery; Michael E Goddard; Peter M Visscher
Journal:  Nat Genet       Date:  2010-06-20       Impact factor: 38.330

6.  Predicting human height by Victorian and genomic methods.

Authors:  Yurii S Aulchenko; Maksim V Struchalin; Nadezhda M Belonogova; Tatiana I Axenovich; Michael N Weedon; Albert Hofman; Andre G Uitterlinden; Manfred Kayser; Ben A Oostra; Cornelia M van Duijn; A Cecile J W Janssens; Pavel M Borodin
Journal:  Eur J Hum Genet       Date:  2009-02-18       Impact factor: 4.246

7.  Common variants in the GDF5-UQCC region are associated with variation in human height.

Authors:  Serena Sanna; Anne U Jackson; Ramaiah Nagaraja; Cristen J Willer; Wei-Min Chen; Lori L Bonnycastle; Haiqing Shen; Nicholas Timpson; Guillaume Lettre; Gianluca Usala; Peter S Chines; Heather M Stringham; Laura J Scott; Mariano Dei; Sandra Lai; Giuseppe Albai; Laura Crisponi; Silvia Naitza; Kimberly F Doheny; Elizabeth W Pugh; Yoav Ben-Shlomo; Shah Ebrahim; Debbie A Lawlor; Richard N Bergman; Richard M Watanabe; Manuela Uda; Jaakko Tuomilehto; Josef Coresh; Joel N Hirschhorn; Alan R Shuldiner; David Schlessinger; Francis S Collins; George Davey Smith; Eric Boerwinkle; Antonio Cao; Michael Boehnke; Gonçalo R Abecasis; Karen L Mohlke
Journal:  Nat Genet       Date:  2008-01-13       Impact factor: 38.330

8.  Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.

Authors:  Nicole Soranzo; Fernando Rivadeneira; Usha Chinappen-Horsley; Ida Malkina; J Brent Richards; Naomi Hammond; Lisette Stolk; Alexandra Nica; Michael Inouye; Albert Hofman; Jonathan Stephens; Eleanor Wheeler; Pascal Arp; Rhian Gwilliam; P Mila Jhamai; Simon Potter; Amy Chaney; Mohammed J R Ghori; Radhi Ravindrarajah; Sergey Ermakov; Karol Estrada; Huibert A P Pols; Frances M Williams; Wendy L McArdle; Joyce B van Meurs; Ruth J F Loos; Emmanouil T Dermitzakis; Kourosh R Ahmadi; Deborah J Hart; Willem H Ouwehand; Nicholas J Wareham; Inês Barroso; Manjinder S Sandhu; David P Strachan; Gregory Livshits; Timothy D Spector; André G Uitterlinden; Panos Deloukas
Journal:  PLoS Genet       Date:  2009-04-03       Impact factor: 5.917

9.  Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci.

Authors:  Markus Perola; Sampo Sammalisto; Tero Hiekkalinna; Nick G Martin; Peter M Visscher; Grant W Montgomery; Beben Benyamin; Jennifer R Harris; Dorret Boomsma; Gonneke Willemsen; Jouke-Jan Hottenga; Kaare Christensen; Kirsten Ohm Kyvik; Thorkild I A Sørensen; Nancy L Pedersen; Patrik K E Magnusson; Tim D Spector; Elisabeth Widen; Karri Silventoinen; Jaakko Kaprio; Aarno Palotie; Leena Peltonen
Journal:  PLoS Genet       Date:  2007-05-02       Impact factor: 5.917

10.  Selective blockade of microRNA processing by Lin28.

Authors:  Srinivas R Viswanathan; George Q Daley; Richard I Gregory
Journal:  Science       Date:  2008-02-21       Impact factor: 47.728

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  31 in total

1.  Genome-wide association of copy-number variation reveals an association between short stature and the presence of low-frequency genomic deletions.

Authors:  Andrew Dauber; Yongguo Yu; Michael C Turchin; Charleston W Chiang; Yan A Meng; Ellen W Demerath; Sanjay R Patel; Stephen S Rich; Jerome I Rotter; Pamela J Schreiner; James G Wilson; Yiping Shen; Bai-Lin Wu; Joel N Hirschhorn
Journal:  Am J Hum Genet       Date:  2011-11-23       Impact factor: 11.025

Review 2.  Height matters-from monogenic disorders to normal variation.

Authors:  Claudia Durand; Gudrun A Rappold
Journal:  Nat Rev Endocrinol       Date:  2013-01-22       Impact factor: 43.330

3.  BAYESIAN GROUP LASSO FOR NONPARAMETRIC VARYING-COEFFICIENT MODELS WITH APPLICATION TO FUNCTIONAL GENOME-WIDE ASSOCIATION STUDIES.

Authors:  Jiahan Li; Zhong Wang; Runze Li; Rongling Wu
Journal:  Ann Appl Stat       Date:  2015-06       Impact factor: 2.083

4.  Nutrition Status of Refugee and Host-Country Children: Negotiating for Equal Distribution of Relief Food During Emergencies in Uganda.

Authors:  Joseph Mandre; Dasel Wambua Mulwa Kaindi; Wambui Kogi-Makau
Journal:  J Immigr Minor Health       Date:  2022-03-28

5.  Population-tailored mock genome enables genomic studies in species without a reference genome.

Authors:  Felipe Sabadin; Humberto Fanelli Carvalho; Giovanni Galli; Roberto Fritsche-Neto
Journal:  Mol Genet Genomics       Date:  2021-11-09       Impact factor: 3.291

6.  Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer.

Authors:  Kristina A Williams; S Intidhar Labidi-Galy; Kathryn L Terry; Allison F Vitonis; William R Welch; Annekathryn Goodman; Daniel W Cramer
Journal:  Gynecol Oncol       Date:  2014-01-23       Impact factor: 5.482

7.  The insulin-like growth factor 1 receptor (IGF1R) contributes to reduced size in dogs.

Authors:  Barbara C Hoopes; Maud Rimbault; David Liebers; Elaine A Ostrander; Nathan B Sutter
Journal:  Mamm Genome       Date:  2012-08-18       Impact factor: 2.957

Review 8.  Using height association studies to gain insights into human idiopathic short and syndromic stature phenotypes.

Authors:  Guillaume Lettre
Journal:  Pediatr Nephrol       Date:  2012-09-02       Impact factor: 3.714

9.  Body Mass Index Categories and Attained Height in Portuguese Adults.

Authors:  Rafaela Rosário; Renata Barros; Patrícia Padrão; Rute Santos; Vitor Hugo Teixeira; Oscar Lopes; Nelson Andrade; Andre Moreira; Pedro Moreira
Journal:  Obes Facts       Date:  2018-07-11       Impact factor: 3.942

Review 10.  Genetic architecture of body size in mammals.

Authors:  Kathryn E Kemper; Peter M Visscher; Michael E Goddard
Journal:  Genome Biol       Date:  2012       Impact factor: 13.583

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