| Literature DB >> 21340514 |
Marcus Vinícius Mariano Nascimento1, Pablinny Moreira Galdino, Iziara Ferreira Florentino, Bruno Leite Sampaio, Frederico Argollo Vanderlinde, José Realino de Paula, Elson Alves Costa.
Abstract
This study was performed to determine the antinociceptive and anti-inflammatory activities of ethanolic extract of Lafoensia pacari A. St.-Hil. (PEtExt) stem bark and its fractions using various animal models such as acetic acid-induced abdominal writhing, formalin-induced pain and croton oil-induced ear edema tests. The PEtExt inhibited the acetic acid-induced abdominal writhing, reduced the pain reaction time on both phases of the formalin test and decreased the edema in a dose-dependent manner. Pre-treatment with naloxone did not reverse the antinociceptive effect. Only the ethyl acetate fraction showed antinociceptive and anti-inflammatory effects. Our results also showed that this extract contains compounds with analgesic action independent of anti-inflammatory activity.Entities:
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Year: 2011 PMID： 21340514 DOI： 10.1007/s11418-011-0517-y
Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343