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Literature DB >> 21339706

Drosophila dosage compensation: males are from Mars, females are from Venus.

Plamen Georgiev¹, Sarantis Chlamydas, Asifa Akhtar.

Abstract

Dosage compensation of X-linked genes is a phenomenon of concerted, chromosome-wide regulation of gene expression underpinned by sustained and tightly regulated histone modifications and chromatin remodeling, coupled with constrains of nuclear architecture. This elaborate process allows the accomplishment of regulated expression of genes on the single male X chromosome to levels comparable to those expressed from the two X chromosomes in females. The ribonucleoprotein Male Specific Lethal (MSL) complex is enriched on the male X chromosome and is intricately involved in this process in Drosophila melanogaster. In this review we discuss the recent advances that highlight the complexity lying behind regulation of gene expression by just two-fold.

Entities: Gene Species

Mesh：

Substances：
Histones

Year: 2011 PMID： 21339706 PMCID： PMC3127063 DOI： 10.4161/fly.5.2.14934

Source DB: PubMed Journal: Fly (Austin) ISSN： 1933-6934 Impact factor: 2.160

134 in total

1. Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila.

Authors: A Akhtar; P B Becker
Journal: Mol Cell Date: 2000-02 Impact factor: 17.970

Review 2. Three-dimensional genome organization in interphase and its relation to genome function.

Authors: Sandra Goetze; Julio Mateos-Langerak; Roel van Driel
Journal: Semin Cell Dev Biol Date: 2007-08-25 Impact factor: 7.727

Review 3. X inactivation and the complexities of silencing a sex chromosome.

Authors: Jennifer Chow; Edith Heard
Journal: Curr Opin Cell Biol Date: 2009-05-26 Impact factor: 8.382

4. Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila.

Authors: Jop Kind; Juan M Vaquerizas; Philipp Gebhardt; Marc Gentzel; Nicholas M Luscombe; Paul Bertone; Asifa Akhtar
Journal: Cell Date: 2008-05-30 Impact factor: 41.582

5. Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes.

Authors: Maya Capelson; Yun Liang; Roberta Schulte; William Mair; Ulrich Wagner; Martin W Hetzer
Journal: Cell Date: 2010-02-05 Impact factor: 41.582

6. The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes.

Authors: Huai Deng; Weiguo Zhang; Xiaomin Bao; Janine N Martin; Jack Girton; Jørgen Johansen; Kristen M Johansen
Journal: Chromosoma Date: 2005-06-29 Impact factor: 4.316

7. Chromosome-wide gene-specific targeting of the Drosophila dosage compensation complex.

Authors: Gregor D Gilfillan; Tobias Straub; Elzo de Wit; Frauke Greil; Rosemarie Lamm; Bas van Steensel; Peter B Becker
Journal: Genes Dev Date: 2006-03-17 Impact factor: 11.361

8. The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation.

Authors: Di Tian; Sha Sun; Jeannie T Lee
Journal: Cell Date: 2010-10-29 Impact factor: 41.582

9. A sequence motif within chromatin entry sites directs MSL establishment on the Drosophila X chromosome.

Authors: Artyom A Alekseyenko; Shouyong Peng; Erica Larschan; Andrey A Gorchakov; Ok-Kyung Lee; Peter Kharchenko; Sean D McGrath; Charlotte I Wang; Elaine R Mardis; Peter J Park; Mitzi I Kuroda
Journal: Cell Date: 2008-08-22 Impact factor: 41.582

10. Clustered DNA motifs mark X chromosomes for repression by a dosage compensation complex.

Authors: Patrick McDonel; Judith Jans; Brant K Peterson; Barbara J Meyer
Journal: Nature Date: 2006-11-19 Impact factor: 49.962

12 in total

1. Balancing sex chromosome expression and satisfying the sexes.

Authors: Jamila I Horabin
Journal: Fly (Austin) Date: 2012-01-01 Impact factor: 2.160

Review 2. Divergent actions of long noncoding RNAs on X-chromosome remodelling in mammals and Drosophila achieve the same end result: dosage compensation.

Authors: Subhash C Lakhotia
Journal: J Genet Date: 2015-12 Impact factor: 1.166

3. Sequence signatures involved in targeting the Male-Specific Lethal complex to X-chromosomal genes in Drosophila melanogaster.

Authors: Philge Philip; Fredrik Pettersson; Per Stenberg
Journal: BMC Genomics Date: 2012-03-19 Impact factor: 3.969

4. X Chromosome and Autosome Dosage Responses in Drosophila melanogaster Heads.

Authors: Zhen-Xia Chen; Brian Oliver
Journal: G3 (Bethesda) Date: 2015-04-07 Impact factor: 3.154

5. Stoichiometric balance of protein copy numbers is measurable and functionally significant in a protein-protein interaction network for yeast endocytosis.

Authors: David O Holland; Margaret E Johnson
Journal: PLoS Comput Biol Date: 2018-03-08 Impact factor: 4.475

6. Sequence-specific targeting of dosage compensation in Drosophila favors an active chromatin context.

Authors: Artyom A Alekseyenko; Joshua W K Ho; Shouyong Peng; Marnie Gelbart; Michael Y Tolstorukov; Annette Plachetka; Peter V Kharchenko; Youngsook L Jung; Andrey A Gorchakov; Erica Larschan; Tingting Gu; Aki Minoda; Nicole C Riddle; Yuri B Schwartz; Sarah C R Elgin; Gary H Karpen; Vincenzo Pirrotta; Mitzi I Kuroda; Peter J Park
Journal: PLoS Genet Date: 2012-04-26 Impact factor: 5.917

10. Transcriptome profiling of the honeybee parasite Varroa destructor provides new biological insights into the mite adult life cycle.

Authors: Fanny Mondet; Andrea Rau; Christophe Klopp; Marine Rohmer; Dany Severac; Yves Le Conte; Cedric Alaux
Journal: BMC Genomics Date: 2018-05-04 Impact factor: 3.969