BACKGROUND: In addition to recreational tanning bed use, UV radiation exposures are sometimes sought to self-treat skin conditions. The ability of tanning bed radiation exposure to trigger toxic epidermal necrolysis has not been reported. OBSERVATIONS: A young woman attempted to treat a self-limiting drug hypersensitivity reaction via tanning bed radiation exposure, which resulted in a systemic toxic epidermal necrolysis-like reaction. Studies with cultured keratinocytes and an epithelial cell line reveal that UV-A radiation can synergize with other stimuli such as phorbol esters or interleukin 1 to produce large amounts of tumor necrosis factor, providing a potential mechanism for this exaggerated reaction. CONCLUSION: In addition to inducing photodamage and skin cancer, tanning bed radiation exposure can trigger a toxic epidermal necrolysis-like reaction, possibly via the exaggerated production of keratinocyte cytokines such as tumor necrosis factor.
BACKGROUND: In addition to recreational tanning bed use, UV radiation exposures are sometimes sought to self-treat skin conditions. The ability of tanning bed radiation exposure to trigger toxic epidermal necrolysis has not been reported. OBSERVATIONS: A young woman attempted to treat a self-limiting drug hypersensitivity reaction via tanning bed radiation exposure, which resulted in a systemic toxic epidermal necrolysis-like reaction. Studies with cultured keratinocytes and an epithelial cell line reveal that UV-A radiation can synergize with other stimuli such as phorbol esters or interleukin 1 to produce large amounts of tumor necrosis factor, providing a potential mechanism for this exaggerated reaction. CONCLUSION: In addition to inducing photodamage and skin cancer, tanning bed radiation exposure can trigger a toxic epidermal necrolysis-like reaction, possibly via the exaggerated production of keratinocyte cytokines such as tumor necrosis factor.
Authors: Steven R Feldman; Anthony Liguori; Michael Kucenic; Stephen R Rapp; Alan B Fleischer; Wei Lang; Mandeep Kaur Journal: J Am Acad Dermatol Date: 2004-07 Impact factor: 11.527
Authors: Robert E Hunger; Thomas Hunziker; Urs Buettiker; Lasse R Braathen; Nikhil Yawalkar Journal: J Allergy Clin Immunol Date: 2005-08-19 Impact factor: 10.793
Authors: M Caproni; D Torchia; E Schincaglia; W Volpi; A Frezzolini; D Schena; A Marzano; P Quaglino; C De Simone; A Parodi; E Barletta; P Fabbri Journal: Br J Dermatol Date: 2006-10 Impact factor: 9.302