Literature DB >> 21338913

Cystic fibrosis: CFTR correctors to the rescue.

David N Sheppard1.   

Abstract

Cystic fibrosis transmembrane conductance regulator (CFTR) correctors are small molecules that target the most common cause of cystic fibrosis: misfolded F508del-CFTR. Using differential scanning fluorimetry, Sampson et al. (2010) identify a CFTR corrector that interacts directly with the CFTR domain affected by the F508del mutation.
Copyright © 2011 Elsevier Ltd. All rights reserved.

Entities:  

Year:  2011        PMID： 21338913     DOI： 10.1016/j.chembiol.2011.02.003

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  5 in total

1.  Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1).

Authors:  Surtaj H Iram; Susan P C Cole
Journal:  J Biol Chem       Date:  2012-01-09       Impact factor: 5.157

Review 2.  Nonequilibrium gating of CFTR on an equilibrium theme.

Authors:  Kang-Yang Jih; Tzyh-Chang Hwang
Journal:  Physiology (Bethesda)       Date:  2012-12

3.  Development of CFTR Structure.

Authors:  Anna E Patrick; Philip J Thomas
Journal:  Front Pharmacol       Date:  2012-09-06       Impact factor: 5.810

4.  Computational design of a PDZ domain peptide inhibitor that rescues CFTR activity.

Authors:  Kyle E Roberts; Patrick R Cushing; Prisca Boisguerin; Dean R Madden; Bruce R Donald
Journal:  PLoS Comput Biol       Date:  2012-04-19       Impact factor: 4.475

5.  Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences.

Authors:  Ameena J Haider; Megan H Cox; Natalie Jones; Alice J Goode; Katherine S Bridge; Kelvin Wong; Deborah Briggs; Ian D Kerr
Journal:  Biosci Rep       Date:  2015-07-17       Impact factor: 3.840
  5 in total

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