PURPOSE: Alcohol administered to laboratory animals has been shown to suppress puberty-related hormones and delay puberty by interfering with ovarian development and function. The effects of early substance use on human pubertal development are relatively unexplored. METHODS: This cross-sectional study of 3,106 female adolescents, aged 11-21 years, evaluated the association between prepubertal alcohol and tobacco use and the onset of puberty. Ages at initial breast development, body hair growth, and menarche were self-reported. Prepubertal alcohol and tobacco use were defined as the age at first use before the age of pubertal development and accompanied by regular use. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Cox proportional hazard models. Logistic regression was used to estimate the association between substance use and delayed puberty, defined as lack of breast development by the age of 13 years. RESULTS: Unadjusted models indicated prepubertal tobacco use was associated with a longer time required for breast development (HR = 0.74; 95% CI, 0.65-0.85) and body hair growth (HR = 0.81; 95% CI, 0.71-0.93). Prepubertal alcohol use was associated with late breast development (HR = 0.71; 95% CI, 0.57-0.88). The direction of the observed associations remained consistent after adjusting for covariates, but the magnitude of effects were attenuated and the upper bound of the 95% CIs exceeded the null value. Girls who used alcohol before puberty had four times the odds of having delayed puberty (OR = 3.99; 95% CI, 1.94-8.21) as compared with nonusers. CONCLUSION: The results of this study suggest that the endocrine-disrupting effects of alcohol and tobacco use may alter the timing of pubertal development. These cross-sectional findings warrant further investigation.
PURPOSE:Alcohol administered to laboratory animals has been shown to suppress puberty-related hormones and delay puberty by interfering with ovarian development and function. The effects of early substance use on human pubertal development are relatively unexplored. METHODS: This cross-sectional study of 3,106 female adolescents, aged 11-21 years, evaluated the association between prepubertal alcohol and tobacco use and the onset of puberty. Ages at initial breast development, body hair growth, and menarche were self-reported. Prepubertal alcohol and tobacco use were defined as the age at first use before the age of pubertal development and accompanied by regular use. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Cox proportional hazard models. Logistic regression was used to estimate the association between substance use and delayed puberty, defined as lack of breast development by the age of 13 years. RESULTS: Unadjusted models indicated prepubertal tobacco use was associated with a longer time required for breast development (HR = 0.74; 95% CI, 0.65-0.85) and body hair growth (HR = 0.81; 95% CI, 0.71-0.93). Prepubertal alcohol use was associated with late breast development (HR = 0.71; 95% CI, 0.57-0.88). The direction of the observed associations remained consistent after adjusting for covariates, but the magnitude of effects were attenuated and the upper bound of the 95% CIs exceeded the null value. Girls who used alcohol before puberty had four times the odds of having delayed puberty (OR = 3.99; 95% CI, 1.94-8.21) as compared with nonusers. CONCLUSION: The results of this study suggest that the endocrine-disrupting effects of alcohol and tobacco use may alter the timing of pubertal development. These cross-sectional findings warrant further investigation.
Authors: Danice K Eaton; Laura Kann; Steve Kinchen; Shari Shanklin; James Ross; Joseph Hawkins; William A Harris; Richard Lowry; Tim McManus; David Chyen; Connie Lim; Lisa Whittle; Nancy D Brener; Howell Wechsler Journal: MMWR Surveill Summ Date: 2010-06-04
Authors: Germaine M Buck Louis; L Earl Gray; Michele Marcus; Sergio R Ojeda; Ora H Pescovitz; Selma Feldman Witchel; Wolfgang Sippell; David H Abbott; Ana Soto; Rochelle W Tyl; Jean-Pierre Bourguignon; Niels E Skakkebaek; Shanna H Swan; Mari S Golub; Martin Wabitsch; Jorma Toppari; Susan Y Euling Journal: Pediatrics Date: 2008-02 Impact factor: 7.124
Authors: Jill K Hiney; Vinod K Srivastava; Danielle N Vaden Anderson; Nicole L Hartzoge; William L Dees Journal: Alcohol Clin Exp Res Date: 2017-12-04 Impact factor: 3.455
Authors: MeiLan K Han; Emilio Arteaga-Solis; John Blenis; Ghada Bourjeily; Deborah J Clegg; Dawn DeMeo; Jeanne Duffy; Ben Gaston; Nicola M Heller; Anna Hemnes; Elizabeth Petri Henske; Raksha Jain; Tim Lahm; Lisa H Lancaster; Joyce Lee; Marianne J Legato; Sherry McKee; Reena Mehra; Alison Morris; Y S Prakash; Martin R Stampfli; Rashmi Gopal-Srivastava; Aaron D Laposky; Antonello Punturieri; Lora Reineck; Xenia Tigno; Janine Clayton Journal: Am J Respir Crit Care Med Date: 2018-10-01 Impact factor: 21.405