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Literature DB >> 213383

Analysis of antigenic diversity among human cytomegaloviruses by kinetic neutralization tests with high-titered rabbit antisera.

Abstract

Neutralizing antisera to human cytomegalovirus were produced in rabbits with alkaline-buffered extracts of infected cell cultures. The antibody activity was complement dependent and associated primarily with the 7S immunoglobulin fraction. Antisera with homologous K values greater than 10.00 were shown to be suitable for neutralization kinetic studies and were so used to examine the antigenic relatedness of strains AD169, Davis, Esp, C-87, Kerr, and Towne. Based upon the degree of relationship as determined by normalized K values, antisera to the Davis or AD169 strains discriminated three antigenic groups, and an antiserum to strain Esp discriminated two groups.

Entities: Gene Species

Mesh：

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Year: 1978 PMID： 213383 PMCID： PMC421970 DOI： 10.1128/iai.21.1.151-157.1978

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

22 in total

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Journal: Proc Soc Exp Biol Med Date: 1964-10

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Journal: Virology Date: 1960-09 Impact factor: 3.616

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Authors: B Forghani; N J Schmidt; E H Lennette
Journal: Infect Immun Date: 1976-11 Impact factor: 3.441

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Journal: Appl Microbiol Date: 1972-04

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Authors: H G Haines; R Von Essen; M Benyesh-Melnick; J L Melnick
Journal: Proc Soc Exp Biol Med Date: 1971-12

20 in total

1. The genes encoding the gCIII complex of human cytomegalovirus exist in highly diverse combinations in clinical isolates.

Authors: Lucy Rasmussen; Aimee Geissler; Catherine Cowan; Amanda Chase; Mark Winters
Journal: J Virol Date: 2002-11 Impact factor: 5.103

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Authors: Y Agatsuma; P Fitzpatrick; A Kaul; R Kaul; R Kohli; A V Paves; P L Ogra
Journal: Infect Immun Date: 1979-10 Impact factor: 3.441

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Authors: R Lehner; T Stamminger; M Mach
Journal: J Clin Microbiol Date: 1991-11 Impact factor: 5.948

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Authors: Steven Sijmons; Kim Thys; Mirabeau Mbong Ngwese; Ellen Van Damme; Jan Dvorak; Marnix Van Loock; Guangdi Li; Ruth Tachezy; Laurent Busson; Jeroen Aerssens; Marc Van Ranst; Piet Maes
Journal: J Virol Date: 2015-05-13 Impact factor: 5.103

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Authors: U Utz; W Britt; L Vugler; M Mach
Journal: J Virol Date: 1989-05 Impact factor: 5.103

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Journal: J Clin Microbiol Date: 1988-03 Impact factor: 5.948

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Authors: L C Goldstein; J McDougall; R Hackman; J D Meyers; E D Thomas; R C Nowinski
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Journal: Infect Immun Date: 1980-10 Impact factor: 3.441

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Authors: M Klein; K Schoppel; N Amvrossiadis; M Mach
Journal: J Virol Date: 1999-02 Impact factor: 5.103

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Authors: L Rasmussen; J Mullenax; R Nelson; T C Merigan
Journal: J Virol Date: 1985-08 Impact factor: 5.103